Betatrophin (GM6484) Mouse Recombinant Protein

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.

Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) A mouse knockout library for secreted and transmembrane proteins.Tang T., Li L., Tang J., Li Y., Lin W.Y., Martin F., Grant D., Solloway M., Parker L., Ye W., Forrest W., Ghilardi N., Oravecz T., Platt K.A., Rice D.S., Hansen G.M., Abuin A., Eberhart D.E., Godowski P., Holt K.H., Peterson A., Zambrowicz B.P., de Sauvage F.J.Nat. Biotechnol. 28:749-755(2010) Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism.Ren G., Kim J.Y., Smas C.M.Am. J. Physiol. 303:E334-E351(2012) Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels.Zhang R.Biochem. Biophys. Res. Commun. 424:786-792(2012) Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.Fu Z., Yao F., Abou-Samra A.B., Zhang R.Biochem. Biophys. Res. Commun. 430:1126-1131(2013) Atypical angiopoietin-like protein that regulates ANGPTL3.Quagliarini F., Wang Y., Kozlitina J., Grishin N.V., Hyde R., Boerwinkle E., Valenzuela D.M., Murphy A.J., Cohen J.C., Hobbs H.H.Proc. Natl. Acad. Sci. U.S.A. 109:19751-19756(2012) Betatrophin a hormone that controls pancreatic beta cell proliferation.Yi P., Park J.S., Melton D.A.Cell 153:747-758(2013) Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis.Wang Y., Quagliarini F., Gusarova V., Gromada J., Valenzuela D.M., Cohen J.C., Hobbs H.H.Proc. Natl. Acad. Sci. U.S.A. 110:16109-16114(2013) Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting.Jiao Y., Le Lay J., Yu M., Naji A., Kaestner K.H.Diabetes 63:1283-1288(2014) Perspectives on the activities of ANGPTL8/betatrophin.Yi P., Park J.S., Melton D.A.Cell 159:467-468(2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion.Gusarova V., Alexa C.A., Na A., Stevis P.E., Xin Y., Bonner-Weir S., Cohen J.C., Hobbs H.H., Murphy A.J., Yancopoulos G.D., Gromada J.Cell 159:691-696(2014)

Small volumes of Gm6484 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1458629 is a recombinant protein targeting Gm6484. Also known as Recombinant Mouse Betatrophin. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.