Human NSMCE1 Recombinant Protein – Cat# MBS145971

Non-SMC Element 1 (NSMCE1) Human Recombinant Protein

Name: NSMCE1 Recombinant Protein; Non-SMC Element 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145971
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145971

Description: NSMCE1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 289 amino acids (1-266) and having a molecular mass of 33.0kDa.NSMCE1 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Non-SMC Element 1 (NSMCE1), Recombinant Protein

Full Product Name

Recombinant Human Non-SMC Element 1

Product Gene Name

NSMCE1 recombinant protein

Product Synonym Names

NSMCE1 Human; Non-SMC Element 1 Human Recombinant; Non-SMC Element 1 Homolog (S. Cerevisiae); NSE1; Non-Structural Maintenance of Chromosomes Element 1 Homolog; Non-SMC Element 1 Homolog; EC 6.3.2.-

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMQG STRR MGVMTDVHRR FLQLLMTHGV LEEWDVKRLQ THCYKVHDRN ATVDKLEDFI NNINSVLESL YIEIKRGVTE DDGRPIYALV NLATTSISKM ATDFAENELD LFRKALELII DSETGFASST NILNLVDQLK GKKMRKKEAE QVLQKFVQNK WLIEKEGEFT LHGRAILEME QYIRETYPDA VKICNICHSL LIQGQSCETC GIRMHLPCVA KYFQSNAEPR CPHCNDYWPH EIPKVFDPEK ERESGVLKSN KKSLRSRQH

Host

E Coli

Form/Format

The NSMCE1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

30,855 Da

3D Structure

ModBase 3D Structure for Q8WV22

Product Categories/Family for NSMCE1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of NSMCE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NSMCE1 purchase

MBS145971 is a recombinant protein targeting NSMCE1. Also known as Recombinant Human Non-SMC Element 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NSMCE1. It may not necessarily be applicable to this product.

NCBI GI #

94721324

NCBI GeneID

197370

NCBI Accession #

NP_659547.2

UniProt Primary Accession #

Q8WV22

UniProt Secondary Accession #

Q9P045; Q9P049; D3DWF6

UniProt Related Accession #

Q8WV22

GenBank Nucleotide #

NM_145080.3

NCBI Official Full Name

non-structural maintenance of chromosomes element 1 homolog

NCBI Official Synonym Full Names

non-SMC element 1 homolog (S. cerevisiae)

NCBI Official Symbol

NSMCE1

NCBI Official Synonym Symbols

NSE1

UniProt Protein Name

Non-structural maintenance of chromosomes element 1 homolog

Protein Family

Non-structural maintenance of chromosomes element

UniProt Gene Name

NSMCE1

UniProt Synonym Gene Names

Non-SMC element 1 homolog

UniProt Entry Name

NSE1_HUMAN

NCBI Protein Information

non-structural maintenance of chromosomes element 1 homolog

UniProt Comments for NSMCE1

NSMCE1: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus. Belongs to the NSE1 family.

Protein type: Ubiquitin conjugating system; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: nucleoplasm; chromosome, telomeric region; intracellular membrane-bound organelle; cytoplasm

Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein ubiquitination; DNA repair; DNA recombination

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.