Human PARVA Recombinant Protein – Cat# MBS146110

Parvin Alpha (PARVA) Human Recombinant Protein

Name: PARVA Recombinant Protein; Parvin Alpha; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146110
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146110

Description: PARVA Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-372 a.a) and having a molecular mass of 44.6kDa.PARVA is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Parvin Alpha (PARVA), Recombinant Protein

Full Product Name

Recombinant Human Parvin Alpha

Product Gene Name

PARVA recombinant protein

Product Synonym Names

PARVA Human; Parvin Alpha Human Recombinant; Alpha-parvin; Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2; PARVA; MXRA2

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMAT SPQK SPSVPKSPTP KSPPSRKKDD SFLGKLGGTL ARRKKAKEVS ELQEEGMNAI NLPLSPIPFE LDPEDTMLEE NEVRTMVDPN SRSDPKLQEL MKVLIDWIND VLVGERIIVK DLAEDLYDGQ VLQKLFEKLE SEKLNVAEVT QSEIAQKQKL QTVLEKINET LKLPPRSIKW NVDSVHAKSL VAILHLLVAL SQYFRAPIRL PDHVSIQVVV VQKREGILQS RQIQEEITGN TEALSGRHER DAFDTLFDHA PDKLNVVKKT LITFVNKHLN KLNLEVTELE TQFADGVYLV LLMGLLEGYF VPLHSFFLTP DSFEQKVLNV SFAFELMQDG GLEKPKPRPE DIVNCDLKST LRVLYNLFTK YRNVE.

Host

E Coli

Form/Format

PARVA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

20,625 Da

OMIM

608120

3D Structure

ModBase 3D Structure for Q9NVD7

Product Categories/Family for PARVA recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of PARVA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PARVA purchase

MBS146110 is a recombinant protein targeting PARVA. Also known as Recombinant Human Parvin Alpha. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PARVA. It may not necessarily be applicable to this product.

NCBI GI #

315583337

NCBI GeneID

55742

NCBI Accession #

NP_060692.2

UniProt Primary Accession #

Q9NVD7

UniProt Secondary Accession #

Q96C85; Q9HA48

UniProt Related Accession #

Q9NVD7

GenBank Nucleotide #

NM_018222.4

NCBI Official Full Name

alpha-parvin

NCBI Official Synonym Full Names

parvin, alpha

NCBI Official Symbol

PARVA

NCBI Official Synonym Symbols

MXRA2; CH-ILKBP

UniProt Protein Name

Alpha-parvin

UniProt Synonym Protein Names

Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2

Protein Family

Alpha-parvin

UniProt Gene Name

PARVA

UniProt Synonym Gene Names

MXRA2

UniProt Entry Name

PARVA_HUMAN

NCBI Protein Information

alpha-parvin; actopaxin; calponin-like integrin-linked kinase-binding protein; matrix-remodeling-associated protein 2

NCBI Summary for PARVA

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

UniProt Comments for PARVA

PARVA: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: focal adhesion; lamellipodium; cytoplasm; plasma membrane; cytosol; Z disc; nucleus; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: heterotypic cell-cell adhesion; regulation of cell shape; actin cytoskeleton reorganization; establishment and/or maintenance of cell polarity; sprouting angiogenesis

Research Articles on PARVA

1. alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PARVA recombinant protein

Reference Product	PubMed Publications
ILK recombinant protein	>42 publications with PARVA and ILK
LIMS2 recombinant protein	>2 publications with PARVA and LIMS2
AKT1 recombinant protein	>2 publications with PARVA and AKT1
PXN recombinant protein	>2 publications with PARVA and PXN
TESK1 recombinant protein	>1 publications with PARVA and TESK1

Pathways associated with PARVA recombinant protein

Products by Pathway	Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-extracellular Matrix Interactions Pathway antibodies	Cell-extracellular Matrix Interactions Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Localization Of The PINCH-ILK-PARVIN Complex To Focal Adhesions Pathway antibodies	Localization Of The PINCH-ILK-PARVIN Complex To Focal Adhesions Pathway Diagram
Regulation Of Cytoskeletal Remodeling And Cell Spreading By IPP Complex Components Pathway antibodies	Regulation Of Cytoskeletal Remodeling And Cell Spreading By IPP Complex Components Pathway Diagram

Diseases associated with PARVA recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>30 publications with PARVA and Cardiovascular Diseases
Inflammation Antibodies	>19 publications with PARVA and Inflammation
Lung Diseases Antibodies	>16 publications with PARVA and Lung Diseases
Disease Models, Animal Antibodies	>13 publications with PARVA and Disease Models, Animal
Nervous System Diseases Antibodies	>13 publications with PARVA and Nervous System Diseases
Necrosis Antibodies	>13 publications with PARVA and Necrosis
Anemia Antibodies	>12 publications with PARVA and Anemia
Liver Diseases Antibodies	>10 publications with PARVA and Liver Diseases
Edema Antibodies	>9 publications with PARVA and Edema
Weight Gain Antibodies	>7 publications with PARVA and Weight Gain

Organs/Tissues associated with PARVA recombinant protein

Organ/Tissue Name	Pubmed Publications
Salivary Gland Antibodies	>75 publications with PARVA and Salivary Gland
Mouth Antibodies	>63 publications with PARVA and Mouth
Vascular Antibodies	>39 publications with PARVA and Vascular
Intestine Antibodies	>28 publications with PARVA and Intestine
Brain Antibodies	>28 publications with PARVA and Brain
Liver Antibodies	>26 publications with PARVA and Liver
Muscle Antibodies	>25 publications with PARVA and Muscle
Bone Antibodies	>20 publications with PARVA and Bone
Kidney Antibodies	>17 publications with PARVA and Kidney
Skin Antibodies	>16 publications with PARVA and Skin