Mouse mI TAC Active Protein – Cat# MBS146535

I-TAC (mI TAC) Mouse Active Protein

Name: mI TAC Active Protein; I-TAC; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS146535
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146535

Description: I TAC Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.Introduction: Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

I-TAC (mI TAC), Active Protein

Full Product Name

Recombinant Mouse I-TAC (CXCL11)

Product Gene Name

mI TAC active protein

Product Synonym Names

I TAC Mouse; I-TAC (CXCL11) Mouse Recombinant; C-X-C motif chemokine 11; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11; Cxcl11; Scyb11

Sequence

FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM

Host

E Coli

Form/Format

I TAC protein was lyophilized from a 0.2 um filtered concentrated solution in 10 mM Sodium Citrate, pH 4.0, with 600 mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Molecular Weight

11,266 Da

3D Structure

ModBase 3D Structure for Q9JHH5

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized I TAC in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100 ng/ml corresponding to a specific activity of 10,000-100,000 IU/mg.

Product Categories/Family for mI TAC active protein

Chemokines; I-TAC (CXCL11)

Other Notes

Small volumes of mI TAC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mI TAC purchase

MBS146535 is an active protein targeting mI TAC. Also known as Recombinant Mouse I-TAC (CXCL11). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mI TAC. It may not necessarily be applicable to this product.

NCBI GI #

9507071

NCBI GeneID

56066

NCBI Accession #

NP_062367.1

UniProt Primary Accession #

Q9JHH5

UniProt Related Accession #

Q9JHH5

GenBank Nucleotide #

NM_019494.1

NCBI Official Full Name

C-X-C motif chemokine 11

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 11

NCBI Official Symbol

Cxcl11

NCBI Official Synonym Symbols

Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1

UniProt Protein Name

C-X-C motif chemokine 11

UniProt Synonym Protein Names

Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11

Protein Family

Tail assembly protein

UniProt Gene Name

Cxcl11

UniProt Synonym Gene Names

Scyb11; I-TAC

UniProt Entry Name

CXL11_MOUSE

NCBI Protein Information

C-X-C motif chemokine 11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small-inducible cytokine B11

UniProt Comments for mI TAC

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation

Research Articles on mI TAC

1. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mI TAC active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with mI TAC active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>187 publications with mI TAC and Inflammation
Necrosis Antibodies	>81 publications with mI TAC and Necrosis
Lung Diseases Antibodies	>61 publications with mI TAC and Lung Diseases
Disease Models, Animal Antibodies	>56 publications with mI TAC and Disease Models, Animal
Liver Diseases Antibodies	>35 publications with mI TAC and Liver Diseases
Cardiovascular Diseases Antibodies	>30 publications with mI TAC and Cardiovascular Diseases
Fibrosis Antibodies	>28 publications with mI TAC and Fibrosis
Death Antibodies	>23 publications with mI TAC and Death
Kidney Diseases Antibodies	>22 publications with mI TAC and Kidney Diseases
Adenocarcinoma Antibodies	>19 publications with mI TAC and Adenocarcinoma

Organs/Tissues associated with mI TAC active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>358 publications with mI TAC and Blood
Lung Antibodies	>83 publications with mI TAC and Lung
Liver Antibodies	>44 publications with mI TAC and Liver
Kidney Antibodies	>34 publications with mI TAC and Kidney
Brain Antibodies	>34 publications with mI TAC and Brain
Spleen Antibodies	>24 publications with mI TAC and Spleen
Eye Antibodies	>23 publications with mI TAC and Eye
Bone Marrow Antibodies	>23 publications with mI TAC and Bone Marrow
Thymus Antibodies	>9 publications with mI TAC and Thymus
Bladder Antibodies	>3 publications with mI TAC and Bladder