Human PLGF3 Active Protein – Cat# MBS146733

Placenta Growth Factor-3 (PLGF3) Human Active Protein

Name: PLGF3 Active Protein; Placenta Growth Factor-3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146733
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146733

Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa. The PLGF-3 is purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Placenta Growth Factor-3 (PLGF3), Active Protein

Full Product Name

Recombinant Human Placenta Growth Factor-3, sf9

Product Gene Name

PLGF3 active protein

Product Synonym Names

PLGF3 Human, sf9; Placental Growth Factor; Placental Growth Factor Vascular Endothelial Growth Factor-Related Protein; PGFL; PLGF; Placental Growth Factor-Like; Placenta Growth Factor; SHGC-10760; D12S1900; PlGF-2; PGF; Placenta Growth Factor-3 Human Recombinant, sf9

Host

Spodoptera frugiperda

Form/Format

Sterile filtered white lyophilized (freeze-dried) powder.
PLGF-3 protein was lyophilized from a 0.2 um filtered solution in HCl.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PLGF-3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

27,402 Da

OMIM

X54936 mRNA

3D Structure

ModBase 3D Structure for P49763

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized PLGF3 in sterile 4mM HCl not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50, as measured by its binding ability to rHuVEGF R1 in a functional ELISA, is less than 3ng/ml.

Product Categories/Family for PLGF3 active protein

Cytokines and Growth Factors

Other Notes

Small volumes of PLGF3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLGF3 purchase

MBS146733 is an active protein targeting PLGF3. Also known as Recombinant Human Placenta Growth Factor-3, sf9. Host: Spodoptera frugiperda.

Additional Details

NCBI/Uniprot data below describe general gene information for PLGF3. It may not necessarily be applicable to this product.

NCBI GI #

333033785

NCBI GeneID

5228

NCBI Accession #

NP_001193941.1

UniProt Primary Accession #

P49763

UniProt Secondary Accession #

Q07101; Q9BV78; Q9Y6S8

UniProt Related Accession #

P49763

GenBank Nucleotide #

NM_001207012.1

NCBI Official Full Name

placenta growth factor isoform 2

NCBI Official Synonym Full Names

placental growth factor

NCBI Official Symbol

PGF

NCBI Official Synonym Symbols

PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760

UniProt Protein Name

Placenta growth factor

UniProt Gene Name

PGF

UniProt Synonym Gene Names

PGFL; PLGF; PlGF

NCBI Protein Information

placenta growth factor

NCBI Summary for PLGF3

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for PLGF3

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular region; extracellular space

Molecular Function: growth factor activity; protein binding; vascular endothelial growth factor receptor binding

Biological Process: angiogenesis; cell-cell signaling; induction of positive chemotaxis; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; response to hypoxia; signal transduction; vascular endothelial growth factor receptor signaling pathway

Research Articles on PLGF3

1. serum level associated with severity of gestational hypertension and pre-eclampsia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLGF3 active protein

Reference Product	PubMed Publications
VEGFA active protein	>20 publications with PLGF3 and VEGFA
FLT1 active protein	>15 publications with PLGF3 and FLT1
IL6 active protein	>12 publications with PLGF3 and IL6
KDR active protein	>8 publications with PLGF3 and KDR
FLT4 active protein	>2 publications with PLGF3 and FLT4
AKT1 active protein	>1 publications with PLGF3 and AKT1
PIK3CA active protein	>1 publications with PLGF3 and PIK3CA
NRP1 active protein	>1 publications with PLGF3 and NRP1

Pathways associated with PLGF3 active protein

Products by Pathway	Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By VEGF Pathway antibodies	Signaling By VEGF Pathway Diagram
VEGF Binds To VEGFR Leading To Receptor Dimerization Pathway antibodies	VEGF Binds To VEGFR Leading To Receptor Dimerization Pathway Diagram
VEGF Ligand-receptor Interactions Pathway antibodies	VEGF Ligand-receptor Interactions Pathway Diagram

Diseases associated with PLGF3 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>369 publications with PLGF3 and Cardiovascular Diseases
Inflammation Antibodies	>274 publications with PLGF3 and Inflammation
Hypertension Antibodies	>191 publications with PLGF3 and Hypertension
Disease Models, Animal Antibodies	>155 publications with PLGF3 and Disease Models, Animal
Neoplasms Antibodies	>150 publications with PLGF3 and Neoplasms
Necrosis Antibodies	>148 publications with PLGF3 and Necrosis
Heart Diseases Antibodies	>123 publications with PLGF3 and Heart Diseases
Atherosclerosis Antibodies	>89 publications with PLGF3 and Atherosclerosis
Drug Toxicity Antibodies	>80 publications with PLGF3 and Drug Toxicity
Brain Diseases Antibodies	>69 publications with PLGF3 and Brain Diseases

Organs/Tissues associated with PLGF3 active protein

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>748 publications with PLGF3 and Ovary
Uterus Antibodies	>720 publications with PLGF3 and Uterus
Muscle Antibodies	>497 publications with PLGF3 and Muscle
Heart Antibodies	>241 publications with PLGF3 and Heart
Lung Antibodies	>233 publications with PLGF3 and Lung
Kidney Antibodies	>210 publications with PLGF3 and Kidney
Placenta Antibodies	>199 publications with PLGF3 and Placenta
Embryonic Tissue Antibodies	>195 publications with PLGF3 and Embryonic Tissue
Brain Antibodies	>194 publications with PLGF3 and Brain
Liver Antibodies	>133 publications with PLGF3 and Liver