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MAP3K3 cDNA Clone – Mitogen-Activated Protein Kinase Kinase Kinase 3 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270862

MBS1270862 is a cDNA clone targeting MAP3K3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MAP3K3, cDNA Clone
Full Product Name
MAP3K3 cDNA Clone
Product Gene Name
Sequence
atgaatgaag caaatgtcat gctgccttat tcagggaagg aggagcctgt cctgcctgtg gccatgaccc tgcctctccc aggcaggggc ccgcgatgtg gaactgctgc cactgagggg ggatccagtt ttgtcaatgc agttgtctct gttttacaag ttggagtcac tcttatgctg tacccagttt ctaaactgga gactgtgtgt gccctctggg ctctgagtac ccctgctttg ggcttgggcc taggctgcat tgaaaagagc tga
Molecular Weight
74,089 Da
OMIM
602539
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MAP3K3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP3K3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens mitogen-activated protein kinase kinase kinase 3, mRNA
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 3
NCBI Official Symbol
MAP3K3
NCBI Official Synonym Symbols
MEKK3; MAPKKK3
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 3
UniProt Synonym Protein Names
MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3
UniProt Gene Name
MAP3K3
UniProt Synonym Gene Names
MAPKKK3; MEKK3; MEK kinase 3; MEKK 3
UniProt Entry Name
M3K3_HUMAN
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 3

NCBI Summary for MAP3K3

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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UniProt Comments for MAP3K3

MEKK3: a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; protein kinase activity

Biological Process: MAPKKK cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid autophosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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