Human SYT11 Recombinant Protein – Cat# MBS146881

Synaptotagmin XI (SYT11) Human Recombinant Protein

Name: SYT11 Recombinant Protein; Synaptotagmin XI; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146881
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146881

Description: SYT11 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 418 amino acids (37-431 a.a) and having a molecular mass of 47kDa. SYT11 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Synaptotagmin XI (SYT11), Recombinant Protein

Full Product Name

Recombinant Human Synaptotagmin XI

Product Gene Name

SYT11 recombinant protein

Product Synonym Names

SYT11 Human; Synaptotagmin XI; SytXI; Synaptotagmin 12; KIAA0080; SYT12; Synaptotagmin-11; Synaptotagmin XI Human Recombinant

Sequence

MGSSHHH HHH SSGLVPRGSH MGSWSC CHQQ AEKKQKNPPY KFIHMLKGIS IYPETLSNKK KIIKVRRDKD GPGREGGRRN LLVDAAEAGL LSRDKDPRGP SSGSCIDQLP IKMDYGEELR SPITSLTPGE SKTTSPSSPE EDVMLGSLTF SVDYNFPKKA LVVTIQEAHG LPVMDDQTQG SDPYIKMTIL PDKRHRVKTR VLRKTLDPVF DETFTFYGIP YSQLQDLVLH FLVLSFDRFS RDDVIGEVMV PLAGVDPSTG KVQLTRDIIK RNIQKCISRG ELQVSLSYQP VAQRMTVVVL KARHLPKMDI TGLSGNPYVK VNVYYGRKRI AKKKTHVKKC TLNPIFNESF IYDIPTDLLP DISIEFLVID FDRTTKNEVV GRLILGAHSV TASGAEHWRE VCESPRKPVA KWHSLSEY

Host

E Coli

Form/Format

Sterile filtered colorless solution.
SYT11 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH7.4) and 50% glycerol.

Purity/Purification

Greater than 80% as determined by SDS-PAGE.

Molecular Weight

48,297 Da

OMIM

D38522 mRNA

3D Structure

ModBase 3D Structure for Q9BT88

Product Categories/Family for SYT11 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of SYT11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYT11 purchase

MBS146881 is a recombinant protein targeting SYT11. Also known as Recombinant Human Synaptotagmin XI. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SYT11. It may not necessarily be applicable to this product.

NCBI GI #

216548478

NCBI GeneID

23208

NCBI Accession #

NP_689493.3

UniProt Primary Accession #

Q9BT88

UniProt Secondary Accession #

Q14998; Q5W0D4; Q68CT5; Q8IXU3; Q96SU2

UniProt Related Accession #

Q9BT88

GenBank Nucleotide #

NM_152280.4

NCBI Official Full Name

synaptotagmin-11

NCBI Official Synonym Full Names

synaptotagmin 11

NCBI Official Symbol

SYT11

NCBI Official Synonym Symbols

SYT12; sytXI

UniProt Protein Name

Synaptotagmin-11

UniProt Synonym Protein Names

Synaptotagmin XI; SytXI

Protein Family

Synaptotagmin

UniProt Gene Name

SYT11

UniProt Synonym Gene Names

KIAA0080; SytXI

NCBI Protein Information

synaptotagmin-11

NCBI Summary for SYT11

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

UniProt Comments for SYT11

SYT11: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: axon; dendritic spine; excitatory synapse; neuron projection; phagocytic vesicle; plasma membrane; postsynaptic density; presynaptic active zone membrane; synaptic vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein binding; protein homodimerization activity; syntaxin binding; ubiquitin protein ligase binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; negative regulation of neurotransmitter secretion; plasma membrane repair; protein homotetramerization; regulation of calcium ion-dependent exocytosis; vesicle fusion

Research Articles on SYT11

1. In summary, This study supports the existence of association between Parkinson disease and markers in or around SYT11

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SYT11 recombinant protein

Products by Pathway	Pathway Diagram
Parkinsons Disease Pathway antibodies	Parkinsons Disease Pathway Diagram

Diseases associated with SYT11 recombinant protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>7 publications with SYT11 and Brain Diseases
Nervous System Diseases Antibodies	>6 publications with SYT11 and Nervous System Diseases
Movement Disorders Antibodies	>6 publications with SYT11 and Movement Disorders
Mental Disorders Antibodies	>2 publications with SYT11 and Mental Disorders
Drug Toxicity Antibodies	>1 publications with SYT11 and Drug Toxicity

Organs/Tissues associated with SYT11 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>6 publications with SYT11 and Nerve
Brain Antibodies	>6 publications with SYT11 and Brain
Embryonic Tissue Antibodies	>1 publications with SYT11 and Embryonic Tissue
Pancreas Antibodies	>1 publications with SYT11 and Pancreas