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Disintegrin and Metalloproteinase Domain-Containing Protein 22 (ADAM22) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1469950

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes… More details

$1765 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), Recombinant Protein
Full Product Name
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial
Product Gene Name
ADAM22 recombinant protein
Product Synonym Gene Name
ADAM22
Sequence
SKRQLRRY PRNVEEETKY IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD AKTGITLSGN GVAGTN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
96,637 Da
Sequence Positions
223-736
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
603709
3D Structure
ModBase 3D Structure for Q9P0K1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ADAM22 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAM22 purchase

MBS1469950 is a recombinant protein targeting ADAM22. Also known as Recombinant Human Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAM22. It may not necessarily be applicable to this product.

NCBI GI #
4757722
NCBI GeneID
53616
NCBI Accession #
NP_004185.1
UniProt Primary Accession #
Q9P0K1
UniProt Secondary Accession #
O75075; O75076; Q9P0K2; Q9UIA1; Q9UKK2
UniProt Related Accession #
Q9P0K1
GenBank Nucleotide #
NM_004194.4
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 22 isoform 4
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 22
NCBI Official Symbol
ADAM22
NCBI Official Synonym Symbols
MDC2; ADAM 22
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 22
UniProt Synonym Protein Names
Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Protein Family
Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name
ADAM22
UniProt Synonym Gene Names
MDC2; ADAM 22
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 22

NCBI Summary for ADAM22

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
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UniProt Comments for ADAM22

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Research Articles on ADAM22

1. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ADAM22 recombinant protein

 Reference Product  PubMed Publications
 LGI1 recombinant protein  >19 publications with ADAM22 and LGI1
 LGI2 recombinant protein  >1 publications with ADAM22 and LGI2

Diseases associated with ADAM22 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with ADAM22 and Nervous System Diseases
 Breast Neoplasms Antibodies  >2 publications with ADAM22 and Breast Neoplasms
 Disease Models, Animal Antibodies  >2 publications with ADAM22 and Disease Models, Animal
 Memory Disorders Antibodies  >2 publications with ADAM22 and Memory Disorders
 Inflammation Antibodies  >1 publications with ADAM22 and Inflammation
 Mammary Neoplasms, Animal Antibodies  >1 publications with ADAM22 and Mammary Neoplasms, Animal
 Cognition Disorders Antibodies  >1 publications with ADAM22 and Cognition Disorders

Organs/Tissues associated with ADAM22 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >32 publications with ADAM22 and Nerve
 Brain Antibodies  >25 publications with ADAM22 and Brain
 Embryonic Tissue Antibodies  >6 publications with ADAM22 and Embryonic Tissue
 Eye Antibodies  >2 publications with ADAM22 and Eye
 Ear Antibodies  >2 publications with ADAM22 and Ear
 Kidney Antibodies  >2 publications with ADAM22 and Kidney
 Mammary Gland Antibodies  >1 publications with ADAM22 and Mammary Gland
 Skin Antibodies  >1 publications with ADAM22 and Skin
 Testis Antibodies  >1 publications with ADAM22 and Testis
 Muscle Antibodies  >1 publications with ADAM22 and Muscle
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