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Nuclear Distribution Protein Nude-Like 1 (NDEL1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1471920

This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and… More details

$1060 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear distribution protein nudE-like 1 (Ndel1), Recombinant Protein
Full Product Name
Recombinant Mouse Nuclear distribution protein nudE-like 1 (Ndel1)
Product Gene Name
Ndel1 recombinant protein
Product Synonym Gene Name
Ndel1
Sequence
MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF QEGSRELEAE LEAQLVQAEQ RNRDLQADNQ RLKYEVEALK EKLEHQYAQS YKQVSVLEDD LSQTRAIKEQ LHKYVRELEQ ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE LAVRERQQEV TRKSAPSSPT LDCEKMDSAV QASLSLPATP VGKGTENSFP SPKAIPNGFG TSPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYVPGS VNCGVMNSNG PECPRSGRAT FFHKGAVNGF DPAPPPPGLG SSRPSSAPGM LPLSV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
35,511 Da
Sequence Positions
1-345, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9ERR1
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Ndel1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ndel1 purchase

MBS1471920 is a recombinant protein targeting Ndel1. Also known as Recombinant Mouse Nuclear distribution protein nudE-like 1 (Ndel1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ndel1. It may not necessarily be applicable to this product.

NCBI GI #
238550188
NCBI GeneID
83431
NCBI Accession #
NP_076157.2
UniProt Primary Accession #
Q9ERR1
UniProt Secondary Accession #
Q9D0Q4; Q9EPT6
UniProt Related Accession #
Q9ERR1
GenBank Nucleotide #
NM_023668.2
NCBI Official Full Name
nuclear distribution protein nudE-like 1
NCBI Official Synonym Full Names
nudE neurodevelopment protein 1 like 1
NCBI Official Symbol
Ndel1
NCBI Official Synonym Symbols
NUDEL; MITAP1; mNudel; 2600006O07Rik
UniProt Protein Name
Nuclear distribution protein nudE-like 1
UniProt Synonym Protein Names
Protein mNudE-like; Protein Nudel; mNudE-L
Protein Family
Nuclear distribution protein
UniProt Gene Name
Ndel1
UniProt Synonym Gene Names
Nudel; Protein Nudel; mNudE-L
NCBI Protein Information
nuclear distribution protein nudE-like 1

UniProt Comments for Ndel1

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).
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Research Articles on Ndel1

1. This study showed that Ndel1 Maintain Postnatal CA1 Hippocampus Integrity in mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ndel1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram

Diseases associated with Ndel1 recombinant protein

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >1 publications with Ndel1 and Neurodegenerative Diseases

Organs/Tissues associated with Ndel1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >43 publications with Ndel1 and Brain
 Embryonic Tissue Antibodies  >4 publications with Ndel1 and Embryonic Tissue
 Kidney Antibodies  >2 publications with Ndel1 and Kidney
 Bladder Antibodies  >1 publications with Ndel1 and Bladder
 Blood Antibodies  >1 publications with Ndel1 and Blood
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