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Unconventional Myosin-VI (MYO6) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1479859

This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Unconventional myosin-VI (MYO6), Recombinant Protein
Full Product Name
Recombinant Human Unconventional myosin-VI (MYO6) , partial
Product Gene Name
MYO6 recombinant protein
Product Synonym Gene Name
MYO6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
148,659 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
600970
3D Structure
ModBase 3D Structure for Q9UM54
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MYO6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYO6 purchase

MBS1479859 is a recombinant protein targeting MYO6. Also known as Recombinant Human Unconventional myosin-VI (MYO6) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MYO6. It may not necessarily be applicable to this product.

NCBI GI #
665505983
NCBI GeneID
4646
NCBI Accession #
NP_001287828.1
UniProt Primary Accession #
Q9UM54
UniProt Secondary Accession #
Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; A6H8V4; E1P540
UniProt Related Accession #
Q9UM54
GenBank Nucleotide #
NM_001300899.1
NCBI Official Full Name
unconventional myosin-VI isoform 2
NCBI Official Synonym Full Names
myosin VI
NCBI Official Symbol
MYO6
NCBI Official Synonym Symbols
DFNA22; DFNB37; Myo6-007; Myo6-008
UniProt Protein Name
Unconventional myosin-VI
UniProt Synonym Protein Names
Unconventional myosin-6
Protein Family
Unconventional myosin
UniProt Gene Name
MYO6
UniProt Synonym Gene Names
KIAA0389
NCBI Protein Information
unconventional myosin-VI

NCBI Summary for MYO6

This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
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UniProt Comments for MYO6

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells ().
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Research Articles on MYO6

1. we describe a novel nonsense MYO6 mutation that was responsible for the hearing loss in a Brazilian family

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MYO6 recombinant protein

 Reference Product  PubMed Publications
 GIPC1 recombinant protein  >5 publications with MYO6 and GIPC1
 OTOF recombinant protein  >3 publications with MYO6 and OTOF
 DAB2 recombinant protein  >2 publications with MYO6 and DAB2
 OPTN recombinant protein  >1 publications with MYO6 and OPTN

Pathways associated with MYO6 recombinant protein

 Products by Pathway  Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway antibodies  Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway Diagram
 Trafficking Of AMPA Receptors Pathway antibodies  Trafficking Of AMPA Receptors Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with MYO6 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with MYO6 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with MYO6 and Disease Models, Animal
 Fibrosis Antibodies  >3 publications with MYO6 and Fibrosis
 Cardiomyopathies Antibodies  >2 publications with MYO6 and Cardiomyopathies
 Hypertension Antibodies  >1 publications with MYO6 and Hypertension
 Congenital Abnormalities Antibodies  >1 publications with MYO6 and Congenital Abnormalities
 Proteinuria Antibodies  >1 publications with MYO6 and Proteinuria
 Cell Transformation, Neoplastic Antibodies  >1 publications with MYO6 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >1 publications with MYO6 and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with MYO6 and Carcinoma, Squamous Cell

Organs/Tissues associated with MYO6 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Ear Antibodies  >23 publications with MYO6 and Ear
 Brain Antibodies  >11 publications with MYO6 and Brain
 Intestine Antibodies  >4 publications with MYO6 and Intestine
 Kidney Antibodies  >4 publications with MYO6 and Kidney
 Prostate Antibodies  >3 publications with MYO6 and Prostate
 Embryonic Tissue Antibodies  >2 publications with MYO6 and Embryonic Tissue
 Blood Antibodies  >2 publications with MYO6 and Blood
 Bone Antibodies  >1 publications with MYO6 and Bone
 Nerve Antibodies  >1 publications with MYO6 and Nerve
 Eye Antibodies  >1 publications with MYO6 and Eye
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