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Ribonuclease H2 Subunit B (RNASEH2B) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1482083

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. This protein is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication.… More details

$1005 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ribonuclease H2 subunit B (RNASEH2B), Recombinant Protein
Full Product Name
Recombinant Human Ribonuclease H2 subunit B (RNASEH2B)
Product Synonym Gene Name
RNASEH2B
Sequence
AAGVDCGDGV GARQHVFLVS EYLKDASKKM KNGLMFVKLV NPCSGEGAIY LFNMCLQQLF EVKVFKEKHH SWFINQSVQS GGLLHFATPV DPLFLLLHYL IKADKEGKFQ PLDQVVVDNV FPNCILLLKL PGLEKLLHHV TEEKGNPEID NKKYYKYSKE KTLKWLEKKV NQTVAALKTN NVNVSSRVQS TAFFSGDQAS TDKEEDYIRY AHGLISDYIP KELSDDLSKY LKLPEPSASL PNPPSKKIKL SDEPVEAKED YTKFNTKDLK TEKKNSKMTA AQKALAKVDK SGMKSIDTFF GVKNKKKIGK V
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
29,005 Da
Sequence Positions
2-312, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610181
3D Structure
ModBase 3D Structure for Q5TBB1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RNASEH2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNASEH2B purchase

MBS1482083 is a recombinant protein targeting RNASEH2B. Also known as Recombinant Human Ribonuclease H2 subunit B (RNASEH2B). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RNASEH2B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ribonuclease H2 subunit B isoform 2
NCBI Official Synonym Full Names
ribonuclease H2 subunit B
NCBI Official Symbol
RNASEH2B
NCBI Official Synonym Symbols
AGS2; DLEU8
UniProt Protein Name
Ribonuclease H2 subunit B
UniProt Synonym Protein Names
Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B
Protein Family
UniProt Gene Name
RNASEH2B
UniProt Synonym Gene Names
DLEU8; RNase H2 subunit B; AGS2
NCBI Protein Information
ribonuclease H2 subunit B

NCBI Summary for RNASEH2B

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
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UniProt Comments for RNASEH2B

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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