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TIMP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1488172

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity. More details

$270 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Timp1, Monoclonal Antibody
Full Product Name
Mouse anti- Rat Timp1 monoclonal Antibody
Product Gene Name
Product Synonym Names
Timp-1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4A2B1
Host
Mouse
Species Reactivity
Rat
Form/Format
Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity/Purification
>95%, Protein G Purified
Specificity
Specific for Rat Timp1 denatured and native forms
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles.
3D Structure
ModBase 3D Structure for P30120
Conjugate
Non-conjugated
Immunogen
Recombinant Rat Timp1
Immunogen Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Timp1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-Timp1 antibody
Recommended dilution:
IHC: 1:50-1:500

Immunohistochemistry (IHC) of anti-Timp1 antibody

Immunohistochemistry of paraffin-embedded Rat prostate cancer using MBS1488172 at dilution of 1:100.
Mouse Anti-TIMP1 Monoclonal Antibody – Cat# MBS1488172

Other Notes

Small volumes of anti-Timp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Timp1 purchase

MBS1488172 is an antibody targeting Timp1. Also known as Mouse anti- Rat Timp1 monoclonal Antibody. Reactive in Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Timp1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
metalloproteinase inhibitor 1
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol
Timp1
NCBI Official Synonym Symbols
Timp; TIMP-1
UniProt Protein Name
Metalloproteinase inhibitor 1
UniProt Synonym Protein Names
Tissue inhibitor of metalloproteinases 1; TIMP-1
UniProt Gene Name
Timp1
UniProt Synonym Gene Names
Timp-1; TIMP-1
UniProt Entry Name
TIMP1_RAT
NCBI Protein Information
metalloproteinase inhibitor 1

NCBI Summary for Timp1

acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling [RGD, Feb 2006]

UniProt Comments for Timp1

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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