DNA-Binding Protein Inhibitor Id-2 (ID2) Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; protein complex

Molecular Function: protein binding; protein dimerization activity

Biological Process: cell maturation; circadian regulation of gene expression; embryonic digestive tract morphogenesis; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; locomotor rhythm; mammary gland epithelial cell proliferation; metanephros development; multicellular organismal development; natural killer cell differentiation; negative regulation of B cell differentiation; negative regulation of DNA binding; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron fate commitment; olfactory bulb development; oligodendrocyte development; Peyer's patch development; positive regulation of astrocyte differentiation; positive regulation of blood pressure; positive regulation of erythrocyte differentiation; positive regulation of fat cell differentiation; positive regulation of macrophage differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of lipid metabolic process; transcription, DNA-dependent