Methylated-DNA-Protein-Cysteine Methyltransferase (MGMT) Antibody – Rabbit Polyclonal

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]

MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.

Protein type: Nuclear receptor co-regulator; Apoptosis; EC 2.1.1.63; DNA repair, damage; Methyltransferase

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: membrane; nucleoplasm; nucleus

Molecular Function: calcium ion binding; damaged DNA binding; DNA binding; DNA-methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity

Biological Process: DNA dealkylation; DNA ligation; DNA methylation; DNA repair; positive regulation of DNA repair; regulation of caspase activity; response to drug; response to ethanol; response to folic acid; response to toxin