Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) Antibody – Rabbit Polyclonal

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: adherens junction; apical plasma membrane; cell surface; cilium; cortical actin cytoskeleton; cytoplasmic microtubule; cytoplasmic vesicle; cytosol; filopodium; focal adhesion; growth cone; integral to membrane; lamellipodium; plasma membrane

Molecular Function: actin binding; actin filament binding; alpha-tubulin binding; ATP binding; beta-tubulin binding; calcium channel activity; calmodulin binding; cation channel activity; microtubule binding; osmosensor activity; protein binding; protein kinase binding; protein kinase C binding; SH2 domain binding; stretch-activated, cation-selective, calcium channel activity

Biological Process: actin cytoskeleton reorganization; actin filament organization; calcium ion transport; cell volume homeostasis; cellular calcium ion homeostasis; cortical microtubule organization and biogenesis; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; intercellular junction assembly; microtubule polymerization; multicellular organismal water homeostasis; osmosensory signaling pathway; positive regulation of microtubule depolymerization; positive regulation of vascular permeability; regulation of response to osmotic stress; response to mechanical stimulus; transmembrane transport; vasopressin secretion

Disease: Brachyolmia Type 3; Digital Arthropathy-brachydactyly, Familial; Hereditary Motor And Sensory Neuropathy, Type Iic; Metatropic Dysplasia; Parastremmatic Dwarfism; Scapuloperoneal Spinal Muscular Atrophy; Sodium Serum Level Quantitative Trait Locus 1; Spinal Muscular Atrophy, Distal, Congenital Nonprogressive; Spondyloepiphyseal Dysplasia, Maroteaux Type; Spondylometaphyseal Dysplasia, Kozlowski Type