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Alkylated DNA Repair Protein Alkb Homolog 1 (ALKBH1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1492094

Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity).… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alkylated DNA repair protein alkB homolog 1 (ALKBH1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Alkylated DNA repair protein alkB homolog 1 polyclonal Antibody(ALKBH1)
Product Gene Name
anti-ALKBH1 antibody
Product Synonym Names
Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; ALKBH1; ABH; ABH1; ALKBH
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
43,832 Da
OMIM
605345
3D Structure
ModBase 3D Structure for Q13686
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Alkylated DNA repair protein alkB homolog 1 protein(110-389aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48121 / sc-67186
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALKBH1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ALKBH1 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-ALKBH1 antibody

Immunohistochemistry of paraffin-embedded human colon cancer using MBS1492094 at dilution 1:100
Rabbit Anti-ALKBH1 Polyclonal Antibody – Cat# MBS1492094

Other Notes

Small volumes of anti-ALKBH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALKBH1 purchase

MBS1492094 is an antibody targeting ALKBH1. Also known as Rabbit anti-human Alkylated DNA repair protein alkB homolog 1 polyclonal Antibody(ALKBH1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH1. It may not necessarily be applicable to this product.

NCBI GI #
87298840
NCBI GeneID
8846
NCBI Accession #
NP_006011.2
UniProt Primary Accession #
Q13686
UniProt Secondary Accession #
Q8TAU1; Q9ULA7
UniProt Related Accession #
Q13686
GenBank Nucleotide #
NM_006020.2
NCBI Official Full Name
DNA oxidative demethylase ALKBH1
NCBI Official Synonym Full Names
alkB homolog 1, histone H2A dioxygenase
NCBI Official Symbol
ALKBH1
NCBI Official Synonym Symbols
ABH; ABH1; alkB; hABH; ALKBH
UniProt Protein Name
DNA oxidative demethylase ALKBH1
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 1; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1 (EC:4.2.99.18)
Protein Family
DNA demethylase
UniProt Gene Name
ALKBH1
UniProt Synonym Gene Names
ABH; ABH1; ALKBH
UniProt Entry Name
ALKB1_HUMAN
NCBI Protein Information
DNA oxidative demethylase ALKBH1

NCBI Summary for ALKBH1

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

UniProt Comments for ALKBH1

ALKBH: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. Belongs to the alkB family.

Protein type: EC 1.14.11.33; DNA repair, damage; EC 4.2.99.18

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: mitochondrion; nucleus

Molecular Function: DNA-(apurinic or apyrimidinic site) lyase activity; ferrous iron binding

Biological Process: DNA dealkylation; DNA repair; RNA repair
Show more

Research Articles on ALKBH1

1. AlkB has a wide variety of substrates, including monoalkyl and exocyclic bridged adducts. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALKBH1 antibody

 Reference Product  PubMed Publications
 ALKBH3 antibody  >6 publications with ALKBH1 and ALKBH3
 ALKBH2 antibody  >4 publications with ALKBH1 and ALKBH2
 ALKBH8 antibody  >4 publications with ALKBH1 and ALKBH8
 ALKBH4 antibody  >2 publications with ALKBH1 and ALKBH4
 ALKBH7 antibody  >2 publications with ALKBH1 and ALKBH7

Pathways associated with anti-ALKBH1 antibody

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with anti-ALKBH1 antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >1 publications with ALKBH1 and Neurodegenerative Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with ALKBH1 and Craniofacial Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with ALKBH1 and Neoplasms, Experimental
 Inflammation Antibodies  >1 publications with ALKBH1 and Inflammation

Organs/Tissues associated with anti-ALKBH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with ALKBH1 and Testis
 Lung Antibodies  >3 publications with ALKBH1 and Lung
 Bone Antibodies  >2 publications with ALKBH1 and Bone
 Placenta Antibodies  >1 publications with ALKBH1 and Placenta
 Eye Antibodies  >1 publications with ALKBH1 and Eye
 Blood Antibodies  >1 publications with ALKBH1 and Blood
 Connective Tissue Antibodies  >1 publications with ALKBH1 and Connective Tissue
 Skin Antibodies  >1 publications with ALKBH1 and Skin
 Embryonic Tissue Antibodies  >1 publications with ALKBH1 and Embryonic Tissue
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