ENY2 Antibody – Rabbit Polyclonal

ENY2: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Belongs to the ENY2 family.

Protein type: Transcription, coactivator/corepressor; Ubiquitin conjugating system; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: nuclear pore

Molecular Function: chromatin binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity

Biological Process: establishment and/or maintenance of chromatin architecture; histone deubiquitination; poly(A)+ mRNA export from nucleus; positive regulation of transcription, DNA-dependent; protein transport; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter