UDP-Glucose 6-Dehydrogenase (UGDH) Antibody – Rabbit Polyclonal

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.22; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - ascorbate and aldarate; Motility/polarity/chemotaxis; Oxidoreductase; Carbohydrate Metabolism - amino sugar and nucleotide sugar

Chromosomal Location of Human Ortholog: 4p15.1

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity

Biological Process: carbohydrate metabolic process; gastrulation with mouth forming second; glycosaminoglycan biosynthetic process; UDP-glucose metabolic process; UDP-glucuronate biosynthetic process; xenobiotic metabolic process