Rabbit Anti-ACAT2 Polyclonal Antibody – Cat# MBS1494588

Immunohistochemistry of paraffin-embedded human placenta using MBS1494588 at dilution 1:100

Acetyl-Coa Acetyltransferase (ACAT2) Antibody – Rabbit Polyclonal

Name: ACAT2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1494588
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1494588

Acetyl-CoA acetyltransferase 2 (ACAT2), also known as cytosolic acetoacetyl-CoA thiolase, plays a role in regulating lipid metabolism (1). It catalyzes the synthesis of acetoacetyl-CoA from two acetyl-CoA molecules, which is later converted into steroids (2). More details

$230 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Acetyl-CoA acetyltransferase (ACAT2), Polyclonal Antibody

Full Product Name

Rabbit anti-human Acetyl-CoA acetyltransferase, cytosolic polyclonal Antibody(ACAT2)

Product Gene Name

anti-ACAT2 antibody

Product Synonym Names

Recombinant human Acetyl-CoA acetyltransferase; cytosolic protein (1-97aa); Cytosolic acetoacetyl-CoA thiolase; ACAT2; ACTL

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Antigen Affinity Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Molecular Weight

44,643 Da

OMIM

100678

3D Structure

ModBase 3D Structure for Q9BWD1

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Conjugate

Non-conjugated

Immunogen

Recombinant human Acetyl-CoA acetyltransferase, cytosolic protein (1-97aa)

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30279 / sc-30280

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ACAT2 antibody

ELISA (EIA), Immunohistochemistry (IHC)

Application Notes for anti-ACAT2 antibody

Recommended dilution: IHC:1:20-1:200

Other Notes

Small volumes of anti-ACAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACAT2 purchase

MBS1494588 is an antibody targeting ACAT2. Also known as Rabbit anti-human Acetyl-CoA acetyltransferase, cytosolic polyclonal Antibody(ACAT2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACAT2. It may not necessarily be applicable to this product.

NCBI GI #

735997436

NCBI GeneID

NCBI Accession #

NP_001290182.1

UniProt Primary Accession #

Q9BWD1

UniProt Secondary Accession #

Q16146; Q5TCL7; Q8TDM4; B7Z233; E1P5B1

UniProt Related Accession #

Q9BWD1

GenBank Nucleotide #

NM_001303253.1

NCBI Official Full Name

acetyl-CoA acetyltransferase, cytosolic isoform 2

NCBI Official Synonym Full Names

acetyl-CoA acetyltransferase 2

NCBI Official Symbol

ACAT2

UniProt Protein Name

Acetyl-CoA acetyltransferase, cytosolic

UniProt Synonym Protein Names

Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase

Protein Family

Acetyl-CoA acetyltransferase

UniProt Gene Name

ACAT2

UniProt Synonym Gene Names

ACTL

UniProt Entry Name

THIC_HUMAN

NCBI Protein Information

acetyl-CoA acetyltransferase, cytosolic

NCBI Summary for ACAT2

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

UniProt Comments for ACAT2

ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; EC 2.3.1.9; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - tryptophan; Acetyltransferase

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity; protein binding

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency

Research Articles on ACAT2

1. results show that the enzymatic activity of mutant Glu(14)Gly is approximately two times higher than wildtype, and that this increase is primarily due to the increased expression and/or stability of the mutant ACAT2 protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACAT2 antibody

Reference Product	PubMed Publications
HMGCS1 antibody	>3 publications with ACAT2 and HMGCS1
ACACB antibody	>1 publications with ACAT2 and ACACB
HMGCS2 antibody	>1 publications with ACAT2 and HMGCS2
HADHA antibody	>1 publications with ACAT2 and HADHA

Pathways associated with anti-ACAT2 antibody

Products by Pathway	Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies	C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies	C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram

Diseases associated with anti-ACAT2 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>32 publications with ACAT2 and Cardiovascular Diseases
Fatty Liver Antibodies	>20 publications with ACAT2 and Fatty Liver
Liver Diseases Antibodies	>14 publications with ACAT2 and Liver Diseases
Liver Neoplasms Antibodies	>7 publications with ACAT2 and Liver Neoplasms
Disease Models, Animal Antibodies	>7 publications with ACAT2 and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>7 publications with ACAT2 and Carcinoma, Hepatocellular
Nervous System Diseases Antibodies	>6 publications with ACAT2 and Nervous System Diseases
Heart Diseases Antibodies	>5 publications with ACAT2 and Heart Diseases
Weight Gain Antibodies	>4 publications with ACAT2 and Weight Gain
Lung Neoplasms Antibodies	>3 publications with ACAT2 and Lung Neoplasms

Organs/Tissues associated with anti-ACAT2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>81 publications with ACAT2 and Liver
Blood Antibodies	>47 publications with ACAT2 and Blood
Intestine Antibodies	>41 publications with ACAT2 and Intestine
Vascular Antibodies	>8 publications with ACAT2 and Vascular
Heart Antibodies	>7 publications with ACAT2 and Heart
Kidney Antibodies	>4 publications with ACAT2 and Kidney
Brain Antibodies	>4 publications with ACAT2 and Brain
Connective Tissue Antibodies	>3 publications with ACAT2 and Connective Tissue
Bone Antibodies	>3 publications with ACAT2 and Bone
Adrenal Gland Antibodies	>3 publications with ACAT2 and Adrenal Gland