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Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 2 (ALKBH2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1494597

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2), Polyclonal Antibody
Full Product Name
Rabbit anti-human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 polyclonal Antibody(ALKBH2)
Product Gene Name
Product Synonym Names
Alkylated DNA repair protein alkB homolog 2; DNA oxidative demethylase ALKBH2; Oxy DC1; ALKBH2; ABH2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
17,083 Da
OMIM
610602
3D Structure
ModBase 3D Structure for Q6NS38
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 protein (1-261aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161335
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALKBH2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ALKBH2 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-ALKBH2 antibody

Immunohistochemistry of paraffin-embedded human small intestine using MBS1494597 at dilution 1:100
Rabbit Anti-ALKBH2 Polyclonal Antibody – Cat# MBS1494597

Immunohistochemistry (IHC) of anti-ALKBH2 antibody

Immunohistochemistry of paraffin-embedded human kidney using MBS1494597 at dilution 1:100
Rabbit Anti-ALKBH2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1494597

Other Notes

Small volumes of anti-ALKBH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALKBH2 purchase

MBS1494597 is an antibody targeting ALKBH2. Also known as Rabbit anti-human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 polyclonal Antibody(ALKBH2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA oxidative demethylase ALKBH2 isoform 1
NCBI Official Synonym Full Names
alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
NCBI Official Symbol
ALKBH2
NCBI Official Synonym Symbols
ABH2
UniProt Protein Name
DNA oxidative demethylase ALKBH2
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1
UniProt Gene Name
ALKBH2
UniProt Synonym Gene Names
ABH2
UniProt Entry Name
ALKB2_HUMAN
NCBI Protein Information
DNA oxidative demethylase ALKBH2

NCBI Summary for ALKBH2

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ALKBH2

ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; EC 1.14.11.33; Oxidoreductase; Hydrolase; Demethylase

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: DNA demethylase activity; DNA-N1-methyladenine dioxygenase activity; ferrous iron binding

Biological Process: DNA dealkylation; DNA repair
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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