Methylosome Protein 50 (WDR77) Antibody – Rabbit Polyclonal

The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; methyl-CpG binding; protein binding

Biological Process: establishment and/or maintenance of chromatin architecture; gene expression; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis