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Aldehyde Dehydrogenase X (ALDH1B1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1495829

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. More details

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Product Overview

Online Datasheet in PDF
Product Name
Aldehyde dehydrogenase X (ALDH1B1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Aldehyde dehydrogenase X, mitochondrial polyclonal Antibody(ALDH1B1)
Product Gene Name
anti-ALDH1B1 antibody
Product Synonym Names
Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; ALDH1B1; ALDH5; ALDHX
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
OMIM
100670
3D Structure
ModBase 3D Structure for P30837
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Aldehyde dehydrogenase X, mitochondrial protein (278-517aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107392 / sc-107393
Species
Homo sapiens (Human)
Research Area
Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALDH1B1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALDH1B1 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-ALDH1B1 antibody

All lanes: Aldehyde dehydrogenase X, mitochondrial antibody at 4ug/ml
Lane 1:Hela whole cell lysate
Lane 2:Rat brain tissue
Lane 3:HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 57kDa
Observed band size: 57kDa
Rabbit Anti-ALDH1B1 Polyclonal Antibody – Cat# MBS1495829

Immunohistochemistry (IHC) of anti-ALDH1B1 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495829 at dilution 1:100
Rabbit Anti-ALDH1B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1495829

Immunohistochemistry (IHC) of anti-ALDH1B1 antibody

Immunohistochemistry of paraffin-embedded human testis using MBS1495829 at dilution 1:100
Rabbit Anti-ALDH1B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1495829

Other Notes

Small volumes of anti-ALDH1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH1B1 purchase

MBS1495829 is an antibody targeting ALDH1B1. Also known as Rabbit anti-human Aldehyde dehydrogenase X, mitochondrial polyclonal Antibody(ALDH1B1). Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH1B1. It may not necessarily be applicable to this product.

NCBI GI #
25777730
NCBI GeneID
219
NCBI Accession #
NP_000683.3
UniProt Primary Accession #
P30837
UniProt Secondary Accession #
Q8WX76; Q9BV45; B2R8F0
UniProt Related Accession #
P30837
GenBank Nucleotide #
NM_000692.4
NCBI Official Full Name
aldehyde dehydrogenase X, mitochondrial
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family member B1
NCBI Official Symbol
ALDH1B1
NCBI Official Synonym Symbols
ALDH5; ALDHX
UniProt Protein Name
Aldehyde dehydrogenase X, mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1
Protein Family
Aldehyde dehydrogenase
UniProt Gene Name
ALDH1B1
UniProt Synonym Gene Names
ALDH5; ALDHX
UniProt Entry Name
AL1B1_HUMAN
NCBI Protein Information
aldehyde dehydrogenase X, mitochondrial

NCBI Summary for ALDH1B1

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]
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UniProt Comments for ALDH1B1

ALDH1B1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Belongs to the aldehyde dehydrogenase family.

Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - histidine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.3; Carbohydrate Metabolism - ascorbate and aldarate; Oxidoreductase; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - butanoate; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 9p11.1

Cellular Component: intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; nucleoplasm

Molecular Function: aldehyde dehydrogenase (NAD) activity

Biological Process: carbohydrate metabolic process; ethanol catabolic process; ethanol oxidation; xenobiotic metabolic process
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Research Articles on ALDH1B1

1. ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDH1B1 antibody

 Reference Product  PubMed Publications
 ADH1B antibody  >4 publications with ALDH1B1 and ADH1B

Pathways associated with anti-ALDH1B1 antibody

 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram

Diseases associated with anti-ALDH1B1 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with ALDH1B1 and Lung Neoplasms
 Colonic Neoplasms Antibodies  >3 publications with ALDH1B1 and Colonic Neoplasms
 Breast Neoplasms Antibodies  >2 publications with ALDH1B1 and Breast Neoplasms
 Hemorrhage Antibodies  >1 publications with ALDH1B1 and Hemorrhage
 Death Antibodies  >1 publications with ALDH1B1 and Death
 Congenital Abnormalities Antibodies  >1 publications with ALDH1B1 and Congenital Abnormalities
 Heart Diseases Antibodies  >1 publications with ALDH1B1 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with ALDH1B1 and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ALDH1B1 and Drug-Related Side Effects and Adverse Reactions
 Hyperglycemia Antibodies  >1 publications with ALDH1B1 and Hyperglycemia

Organs/Tissues associated with anti-ALDH1B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with ALDH1B1 and Lung
 Blood Antibodies  >4 publications with ALDH1B1 and Blood
 Liver Antibodies  >4 publications with ALDH1B1 and Liver
 Pancreas Antibodies  >4 publications with ALDH1B1 and Pancreas
 Eye Antibodies  >3 publications with ALDH1B1 and Eye
 Brain Antibodies  >3 publications with ALDH1B1 and Brain
 Lymph Node Antibodies  >2 publications with ALDH1B1 and Lymph Node
 Lymph Antibodies  >2 publications with ALDH1B1 and Lymph
 Adipose Tissue Antibodies  >1 publications with ALDH1B1 and Adipose Tissue
 Heart Antibodies  >1 publications with ALDH1B1 and Heart
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