NCL Antibody – Rabbit Polyclonal

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]

NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly.

Protein type: Nuclear receptor co-regulator; Helicase; DNA-binding; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cell cortex; cell surface; dense fibrillar component; fibrillar center; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: calcium ion binding; histone binding; identical protein binding; laminin binding; nucleotide binding; protein binding; protein C-terminus binding; RNA binding; rRNA primary transcript binding; single-stranded DNA binding; telomeric DNA binding

Biological Process: angiogenesis; endocytosis; negative regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; spermatogenesis