Transforming Growth Factor-Beta-Induced Protein Ig-H3 (TGFBI) Antibody – Rabbit Polyclonal

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.

Protein type: Secreted; Cell adhesion; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; plasma membrane; proteinaceous extracellular matrix; trans-Golgi network

Molecular Function: collagen binding; extracellular matrix binding; integrin binding; protein binding

Biological Process: angiogenesis; cell adhesion; cell proliferation; cellular protein metabolic process; chondrocyte differentiation; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; response to stimulus; visual perception

Disease: Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Groenouw Type I; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy, Lattice Type Iiia