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Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497017

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and… More details

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Product Overview

Online Datasheet in PDF
Product Name
Activating signal cointegrator 1 complex subunit 3 (ASCC3), Polyclonal Antibody
Full Product Name
Rabbit anti-human Activating signal cointegrator 1 complex subunit 3 polyclonal Antibody(ASCC3)
Product Gene Name
anti-ASCC3 antibody
Product Synonym Names
ASC-1 complex subunit p200; ASC1p200; Helicase; ATP binding 1; Trip4 complex subunit p200; ASCC3; HELIC1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
83,675 Da
OMIM
614217
3D Structure
ModBase 3D Structure for Q8N3C0
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Activating signal cointegrator 1 complex subunit 3 protein (1-111aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68558 / sc-68559
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ASCC3 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ASCC3 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-ASCC3 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS1497017 at dilution 1:100
Rabbit Anti-ASCC3 Polyclonal Antibody – Cat# MBS1497017

Immunohistochemistry (IHC) of anti-ASCC3 antibody

Immunohistochemistry of paraffin-embedded human placenta using MBS1497017 at dilution 1:100
Rabbit Anti-ASCC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1497017

Immunohistochemistry (IHC) of anti-ASCC3 antibody

Immunohistochemistry of paraffin-embedded human pancreas using MBS1497017 at dilution 1:100
Rabbit Anti-ASCC3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1497017

Other Notes

Small volumes of anti-ASCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASCC3 purchase

MBS1497017 is an antibody targeting ASCC3. Also known as Rabbit anti-human Activating signal cointegrator 1 complex subunit 3 polyclonal Antibody(ASCC3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ASCC3. It may not necessarily be applicable to this product.

NCBI GI #
546232111
NCBI GeneID
10973
NCBI Accession #
NP_001271200.1
UniProt Primary Accession #
Q8N3C0
UniProt Secondary Accession #
O43738; Q4G1A0; Q5VTN2; Q9H1I9; Q9H5A2; Q9NTR0; E7EW23
UniProt Related Accession #
Q8N3C0
GenBank Nucleotide #
NM_001284271.1
NCBI Official Full Name
activating signal cointegrator 1 complex subunit 3 isoform c
NCBI Official Synonym Full Names
activating signal cointegrator 1 complex subunit 3
NCBI Official Symbol
ASCC3
NCBI Official Synonym Symbols
RNAH; HELIC1; ASC1p200
UniProt Protein Name
Activating signal cointegrator 1 complex subunit 3
UniProt Synonym Protein Names
ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200
Protein Family
Activating signal cointegrator 1 complex
UniProt Gene Name
ASCC3
UniProt Synonym Gene Names
HELIC1; ASC1p200
UniProt Entry Name
ASCC3_HUMAN
NCBI Protein Information
activating signal cointegrator 1 complex subunit 3

NCBI Summary for ASCC3

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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UniProt Comments for ASCC3

ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: cytoplasm; Golgi apparatus; intracellular; membrane; nucleoplasm; nucleus

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; protein binding

Biological Process: cell proliferation; DNA dealkylation; DNA duplex unwinding; DNA repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on ASCC3

1. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ASCC3 antibody

 Reference Product  PubMed Publications
 CDC5L antibody  >1 publications with ASCC3 and CDC5L

Pathways associated with anti-ASCC3 antibody

 Products by Pathway  Pathway Diagram
 ALKBH3 Mediated Reversal Of Alkylation Damage Pathway antibodies  ALKBH3 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram

Organs/Tissues associated with anti-ASCC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with ASCC3 and Liver
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