Activin Receptor Type-2a (ACVR2A) Antibody – Rabbit Polyclonal

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Protein kinase, TKL; Membrane protein, integral; Motility/polarity/chemotaxis; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: cell surface; cytoplasm; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: activin binding; activin receptor activity; ATP binding; coreceptor activity; growth factor binding; metal ion binding; PDZ domain binding; protein binding; protein self-association; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; BMP signaling pathway; determination of left/right symmetry; embryonic skeletal development; gastrulation with mouth forming second; mesoderm development; penile erection; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of BMP signaling pathway; regulation of nitric-oxide synthase activity; Sertoli cell proliferation; sperm ejaculation; spermatogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway