Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT1) Antibody – Rabbit Polyclonal

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Adaptor/scaffold; Nuclear export; Protease; Ligase; Ubiquitin conjugating system; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: CBM complex; cytoplasm; cytosol; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function: cysteine-type endopeptidase activity; kinase activator activity; peptidase activity; protease binding; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; B-1 B cell differentiation; defense response; innate immune response; negative regulation of apoptosis; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of T cell cytokine production; protein oligomerization; protein ubiquitination; proteolysis; regulation of apoptosis; regulation of T cell receptor signaling pathway; response to fungus; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell proliferation; T cell receptor signaling pathway

Disease: Immunodeficiency 12