Phosphoinositide 3-Kinase Regulatory Subunit 5 (PIK3R5) Antibody – Rabbit Polyclonal

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

PIK3R5: Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase regulator activity; G-protein beta/gamma-subunit binding

Biological Process: blood coagulation; G-protein coupled receptor protein signaling pathway; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phospholipid metabolic process; platelet activation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; regulation of phosphoinositide 3-kinase activity

Disease: Ataxia-oculomotor Apraxia 3