Endothelial Transcription Factor GATA-2 (GATA2) Antibody – Rabbit Polyclonal

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytosol; mast cell granule; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; transcription factor activity; transcription factor binding; zinc ion binding

Biological Process: anatomical structure formation; blood coagulation; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; commitment of a neuronal cell to a specific type of neuron in the forebrain; elevation of cytosolic calcium ion concentration; embryonic placenta development; gut development; heart development; homeostasis of number of cells within a tissue; inner ear morphogenesis; mast cell degranulation; negative regulation of fat cell differentiation; negative regulation of macrophage differentiation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron migration; organ morphogenesis; phagocytosis; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of transcription from RNA polymerase II promoter; regulation of histone acetylation; response to lipid; somatic stem cell maintenance; tissue development; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urogenital system development; ventral spinal cord interneuron differentiation

Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome