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PKDCC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150058

VLK Antibody: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VLK (Pkdcc), Polyclonal Antibody
Full Product Name
VLK Antibody
Product Gene Name
anti-Pkdcc antibody
Product Synonym Names
VLK; Vlk; MAd1; Adtk1; ESTM17; Sgk493; X83346; AI115348; AW548124; Vlk; Protein kinase domain-containing protein; cytoplasmic; Protein kinase-like protein SgK493; protein kinase domain containing, cytoplasmic
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
VLK Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
VLK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
VLK peptide (MBS152351) is used for blocking the activity of VLK antibody (MBS150058)
Molecular Weight
48,988 Da
3D Structure
ModBase 3D Structure for Q5RJI4
Conjugate
Unconjugated
Immunogen
VLK antibody was raised against a 15 amino acid synthetic peptide from near the center of human VLK.
Buffer
VLK Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-Pkdcc antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-Pkdcc antibody
VLK antibody can be used for detection of VLK by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL.

Western Blot (WB) of anti-Pkdcc antibody

Western blot analysis of VLK in human lung tissue lysate with VLK antibody at 1 μg/mL.
Rabbit Anti-PKDCC Polyclonal Antibody – Cat# MBS150058

Immunohistochemistry (IHC) of anti-Pkdcc antibody

Immunohistochemistry of VLK in rat lung tissue with VLK antibody at 2.5 μg/mL.
Rabbit Anti-PKDCC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150058

Immunofluorescence (IF) of anti-Pkdcc antibody

Immunofluorescence of VLK in rat lung tissue with VLK antibody at 5 μg/mL.
Rabbit Anti-PKDCC Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150058

Western Blot (WB) of anti-Pkdcc antibody

Western blot analysis of VLK expression in Jurkat cell lysate with VLK antibody at 0.5 μg/ml.
Rabbit Anti-PKDCC Polyclonal Antibody, Western Blot (WB) – Cat# MBS150058

Other Notes

Small volumes of anti-Pkdcc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pkdcc purchase

MBS150058 is an antibody targeting Pkdcc. Also known as VLK Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Pkdcc. It may not necessarily be applicable to this product.

NCBI GI #
238636897
NCBI GeneID
106522
NCBI Accession #
NP_612379
UniProt Primary Accession #
Q5RJI4
UniProt Secondary Accession #
Q3UZD3; Q8VBZ6; B6F136
UniProt Related Accession #
Q5RJI4
NCBI Official Full Name
vertebrate lonesome kinase
NCBI Official Synonym Full Names
protein kinase domain containing, cytoplasmic
NCBI Official Symbol
Pkdcc
NCBI Official Synonym Symbols
Vlk; MAd1; Adtk1; ESTM17; Sgk493; X83346; AI115348; AW548124
UniProt Protein Name
Extracellular tyrosine-protein kinase PKDCC
UniProt Synonym Protein Names
Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493Sugen kinase 493Vertebrate lonesome kinase
Protein Family
Extracellular tyrosine-protein kinase
UniProt Gene Name
Pkdcc
UniProt Entry Name
PKDCC_MOUSE
NCBI Protein Information
extracellular tyrosine-protein kinase PKDCC; sugen kinase 493; vertebrate lonesome kinase; protein kinase-like protein SgK493; protein kinase domain-containing protein, cytoplasmic

UniProt Comments for Pkdcc

PKDCC: Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane. Belongs to the protein kinase superfamily.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, Other; Other group; SgK493 family

Cellular Component: Golgi apparatus; extracellular region

Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: ossification; peptidyl-tyrosine phosphorylation; multicellular organismal development; multicellular organism growth; negative regulation of Golgi to plasma membrane protein transport; palate development; positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; bone mineralization; protein transport; positive regulation of chondrocyte differentiation; transport; cell differentiation; alveolus development; skeletal development; embryonic gut development; phosphorylation
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Research Articles on Pkdcc

1. VLK plays a role in the Indian hedgehog /GLI3 interactions and that Vlk and Gli3 cooperate to regulate long bone development

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Pkdcc antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with Pkdcc and Congenital Abnormalities

Organs/Tissues associated with anti-Pkdcc antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >4 publications with Pkdcc and Bone
 Other Antibodies  >2 publications with Pkdcc and Other
 Intestine Antibodies  >1 publications with Pkdcc and Intestine
 Embryonic Tissue Antibodies  >1 publications with Pkdcc and Embryonic Tissue
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