SIRT4 Antibody – Chicken Polyclonal

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

SIRT4: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. Belongs to the sirtuin family. Class II subfamily.

Protein type: Mitochondrial; Tumor suppressor; Deacetylase; EC 2.4.2.-; EC 3.5.1.-

Chromosomal Location of Human Ortholog: 12q

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; zinc ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; chromatin silencing; glutamine metabolic process; positive regulation of lipid biosynthetic process; response to DNA damage stimulus; negative regulation of fatty acid oxidation; negative regulation of insulin secretion