Rabbit Anti-ZC3H12D Polyclonal Antibody – Cat# MBS150729

Western blot analysis of ZC3H12D in human spleen tissue lysate with ZC3H12D antibody at 1 μg/mL.

ZC3H12D Antibody – Rabbit Polyclonal

Name: ZC3H12D Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS150729
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150729

ZC3H12D Antibody: ZC3H12D, also known as MCPIP4, is a member of a family of novel CCCH-zinc finger proteins that includes ZC3H12A, a protein that is thought to be involved in macrophage activation, host immunity and inflammatory diseases. ZC3H12D is highly… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZC3H12D, Polyclonal Antibody

Full Product Name

ZC3H12D Antibody

Product Gene Name

anti-ZC3H12D antibody

Product Synonym Names

ZC3H12D; TFL; p34; MCPIP4; C6orf95; dJ281H8.1; TFL; Probable ribonuclease ZC3H12D; MCP-induced protein 4; zinc finger CCCH-type containing 12D

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

ZC3H12D Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Preparation and Storage

ZC3H12D antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

ZC3H12D peptide (MBS152244) is used for blocking the activity of ZC3H12D antibody (MBS150729)

Molecular Weight

36,199 Da

OMIM

611106

3D Structure

ModBase 3D Structure for A2A288

Conjugate

Unconjugated

Immunogen

ZC3H12D antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZC3H12D.

Buffer

ZC3H12D Antibody is supplied in PBS containing 0.02% sodium azide.

Applications Tested/Suitable for anti-ZC3H12D antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-ZC3H12D antibody

ZC3H12D antibody can be used for detection of ZC3H12D by Western blot at 1 mug/mL.

Other Notes

Small volumes of anti-ZC3H12D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZC3H12D purchase

MBS150729 is an antibody targeting ZC3H12D. Also known as ZC3H12D Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZC3H12D. It may not necessarily be applicable to this product.

NCBI GI #

119568186

NCBI GeneID

340152

NCBI Accession #

EAW47801

UniProt Primary Accession #

A2A288

UniProt Secondary Accession #

Q6ZRW2; A1L178; B2RXF4; B7WNU7; B9ZZP9; B9ZZQ0

UniProt Related Accession #

A2A288

NCBI Official Full Name

hCG1749747, isoform CRA_a

NCBI Official Synonym Full Names

zinc finger CCCH-type containing 12D

NCBI Official Symbol

ZC3H12D

NCBI Official Synonym Symbols

TFL; p34; MCPIP4; C6orf95; dJ281H8.1

UniProt Protein Name

Probable ribonuclease ZC3H12D

UniProt Synonym Protein Names

MCP-induced protein 4; Transformed follicular lymphomaZinc finger CCCH domain-containing protein 12Dp34

Protein Family

Probable ribonuclease

UniProt Gene Name

ZC3H12D

UniProt Entry Name

ZC12D_HUMAN

NCBI Protein Information

probable ribonuclease ZC3H12D; p34; tumor suppressor TFL; transformed follicular lymphoma; Zinc finger CCCH domain-containing protein 12D

UniProt Comments for ZC3H12D

ZC3H12D: May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed. Belongs to the ZC3H12 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.1.-.-

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytoplasm; nucleus

Molecular Function: endonuclease activity; metal ion binding

Biological Process: negative regulation of cell growth

Research Articles on ZC3H12D

1. Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ZC3H12D antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with ZC3H12D and Lung
Spleen Antibodies	>2 publications with ZC3H12D and Spleen
Intestine Antibodies	>2 publications with ZC3H12D and Intestine
Lymph Node Antibodies	>1 publications with ZC3H12D and Lymph Node