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APBA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150799

APBA1 Antibody: The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). APBA1 stabilizes APP… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
APBA1, Polyclonal Antibody
Full Product Name
APBA1 Antibody
Product Gene Name
anti-APBA1 antibody
Product Synonym Names
APBA1; X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA; X11; Amyloid beta A4 precursor protein-binding family A member 1; Adapter protein X11alpha; Mint-1; amyloid beta A4 precursor protein-binding family A member 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
APBA1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two alternatively spliced isoforms are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other APBA proteins.
Preparation and Storage
APBA1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
APBA1 peptide (MBS152536) is used for blocking the activity of APBA1 antibody (MBS150799)
Molecular Weight
92 kDa
OMIM
602414
3D Structure
ModBase 3D Structure for Q02410
Conjugate
Unconjugated
Immunogen
APBA1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human APBA1.
Buffer
APBA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-APBA1 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-APBA1 antibody
APBA1 antibody can be used for detection of APBA1 by Western blot at 0.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-APBA1 antibody

Western blot analysis of APBA1 in rat brain tissue lysate with APBA1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-APBA1 Polyclonal Antibody – Cat# MBS150799

Immunofluorescence (IF) of anti-APBA1 antibody

Immunofluorescence of APBA1 in human brain tissue with APBA1 antibody at 20 μg/mL.
Rabbit Anti-APBA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150799

Other Notes

Small volumes of anti-APBA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APBA1 purchase

MBS150799 is an antibody targeting APBA1. Also known as APBA1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APBA1. It may not necessarily be applicable to this product.

NCBI GI #
22035548
NCBI GeneID
320
NCBI Accession #
NP_001154
UniProt Primary Accession #
Q02410
UniProt Secondary Accession #
O14914; O60570; Q5VYR8
UniProt Related Accession #
Q02410
GenBank Nucleotide #
NM_001163.3
NCBI Official Full Name
amyloid beta A4 protein-binding family A member 1
NCBI Official Synonym Full Names
amyloid beta (A4) precursor protein-binding, family A, member 1
NCBI Official Symbol
APBA1
NCBI Official Synonym Symbols
X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA
UniProt Protein Name
Amyloid beta A4 precursor protein-binding family A member 1
UniProt Synonym Protein Names
Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1; Mint-1
Protein Family
Amyloid beta A4 precursor protein-binding family
UniProt Gene Name
APBA1
UniProt Synonym Gene Names
MINT1; X11; Mint-1
UniProt Entry Name
APBA1_HUMAN
NCBI Protein Information
amyloid beta A4 precursor protein-binding family A member 1; mint-1; adapter protein X11alpha; adaptor protein X11alpha; neuron-specific X11 protein; neuronal munc18-1-interacting protein 1; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)

NCBI Summary for APBA1

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
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UniProt Comments for APBA1

APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: Golgi apparatus; synaptic vesicle; protein complex; perinuclear region of cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-amyloid binding; protein complex binding; PDZ domain binding

Biological Process: intracellular protein transport; synaptic transmission; nervous system development; glutamate secretion; regulation of gene expression; in utero embryonic development; multicellular organism growth; gamma-aminobutyric acid secretion; axon cargo transport; locomotory behavior; protein complex assembly; cell adhesion
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Research Articles on APBA1

1. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APBA1 antibody

 Reference Product  PubMed Publications
 APP antibody  >38 publications with APBA1 and APP
 CASK antibody  >14 publications with APBA1 and CASK
 KIF17 antibody  >4 publications with APBA1 and KIF17
 PSEN1 antibody  >4 publications with APBA1 and PSEN1
 STXBP1 antibody  >3 publications with APBA1 and STXBP1
 LIN7B antibody  >1 publications with APBA1 and LIN7B
 LIN7A antibody  >1 publications with APBA1 and LIN7A

Diseases associated with anti-APBA1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >51 publications with APBA1 and Brain Diseases
 Ataxia Antibodies  >25 publications with APBA1 and Ataxia
 Intestinal Neoplasms Antibodies  >8 publications with APBA1 and Intestinal Neoplasms
 Death Antibodies  >6 publications with APBA1 and Death
 Inflammation Antibodies  >3 publications with APBA1 and Inflammation
 Adenoma Antibodies  >2 publications with APBA1 and Adenoma
 Seizures Antibodies  >2 publications with APBA1 and Seizures
 Memory Disorders Antibodies  >2 publications with APBA1 and Memory Disorders
 Cognition Disorders Antibodies  >2 publications with APBA1 and Cognition Disorders
 Neoplasms, Experimental Antibodies  >2 publications with APBA1 and Neoplasms, Experimental

Organs/Tissues associated with anti-APBA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >120 publications with APBA1 and Nerve
 Brain Antibodies  >49 publications with APBA1 and Brain
 Embryonic Tissue Antibodies  >6 publications with APBA1 and Embryonic Tissue
 Kidney Antibodies  >6 publications with APBA1 and Kidney
 Pancreas Antibodies  >2 publications with APBA1 and Pancreas
 Muscle Antibodies  >2 publications with APBA1 and Muscle
 Intestine Antibodies  >2 publications with APBA1 and Intestine
 Lung Antibodies  >1 publications with APBA1 and Lung
 Testis Antibodies  >1 publications with APBA1 and Testis
 Mouth Antibodies  >1 publications with APBA1 and Mouth
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