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EVER1 (TMC6) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150929

EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
EVER1 (TMC6), Polyclonal Antibody
Full Product Name
EVER1 Antibody
Product Gene Name
Product Synonym Names
EVER1; EV1; EVER1; EVIN1; LAK-4P; Transmembrane channel-like protein 6; Epidermodysplasia verruciformis protein 1; transmembrane channel-like 6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
EVER1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Preparation and Storage
EVER1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
EVER1 peptide (MBS152431) is used for blocking the activity of EVER1 antibody (MBS150929)
Molecular Weight
32,485 Da
OMIM
phenotype 605828
3D Structure
ModBase 3D Structure for Q7Z403
Conjugate
Unconjugated
Immunogen
EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1.
Buffer
EVER1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TMC6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TMC6 antibody
EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.

Western Blot (WB) of anti-TMC6 antibody

Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-TMC6 Polyclonal Antibody – Cat# MBS150929

Immunohistochemistry (IHC) of anti-TMC6 antibody

Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 μg/mL.
Rabbit Anti-TMC6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150929

Other Notes

Small volumes of anti-TMC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMC6 purchase

MBS150929 is an antibody targeting TMC6. Also known as EVER1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMC6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
large EVER1 protein
NCBI Official Synonym Full Names
transmembrane channel-like 6
NCBI Official Symbol
TMC6
NCBI Official Synonym Symbols
EV1; EVER1; EVIN1; LAK-4P
UniProt Protein Name
Transmembrane channel-like protein 6
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 1; Protein LAK-4
UniProt Gene Name
TMC6
UniProt Synonym Gene Names
EVER1; EVIN1
UniProt Entry Name
TMC6_HUMAN
NCBI Protein Information
transmembrane channel-like protein 6; protein LAK-4; epidermodysplasia verruciformis 1; expressed in activated T/LAK lymphocytes; epidermodysplasia verruciformis protein 1

NCBI Summary for TMC6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
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UniProt Comments for TMC6

TMC6: Defects in TMC6 are a cause of epidermodysplasia verruciformis (EV). It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Belongs to the TMC family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Molecular Function: protein binding

Biological Process: ion transport

Disease: Epidermodysplasia Verruciformis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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