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AES Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150968

AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
AES, Polyclonal Antibody
Full Product Name
AES Antibody
Product Gene Name
anti-AES antibody
Product Synonym Names
AES; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; GRG; Amino-terminal enhancer of split; Gp130-associated protein GAM; Amino enhancer of split; amino-terminal enhancer of split
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
AES Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
AES antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
AES peptide (MBS152200) is used for blocking the activity of AES antibody (MBS150968)
Molecular Weight
29,091 Da
OMIM
600188
3D Structure
ModBase 3D Structure for Q08117
Conjugate
Unconjugated
Immunogen
AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES.
Buffer
AES Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-AES antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-AES antibody
AES antibody can be used for the detection of AES by Western blot at 1 - 4 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-AES antibody

Western blot analysis of AES in 293 cell lysate with AES antibody at (A) 1, (B) 2 and (C) 4 μg/mL.
Rabbit Anti-AES Polyclonal Antibody – Cat# MBS150968

Immunocytochemistry (IHC) of anti-AES antibody

Immunocytochemistry of AES in HeLa cells with AES antibody at 10 μg/mL.
Rabbit Anti-AES Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150968

Immunofluorescence (IF) of anti-AES antibody

Immunofluorescence of AES in Hela cells with AES antibody at 20 μg/mL.
Rabbit Anti-AES Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150968

Other Notes

Small volumes of anti-AES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AES purchase

MBS150968 is an antibody targeting AES. Also known as AES Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AES. It may not necessarily be applicable to this product.

NCBI GI #
39812019
NCBI GeneID
166
NCBI Accession #
NP_945320
UniProt Primary Accession #
Q08117
UniProt Secondary Accession #
Q12808; Q14CJ1; Q96TG9; Q9UDY9; B2RBL0
UniProt Related Accession #
Q08117
GenBank Nucleotide #
NM_198969.1
NCBI Official Full Name
amino-terminal enhancer of split isoform a
NCBI Official Synonym Full Names
amino-terminal enhancer of split
NCBI Official Symbol
AES
NCBI Official Synonym Symbols
GRG; ESP1; GRG5; TLE5; AES-1; AES-2; Grg-5
UniProt Protein Name
Amino-terminal enhancer of split
UniProt Synonym Protein Names
Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG
Protein Family
Acetyl esterase
UniProt Gene Name
AES
UniProt Synonym Gene Names
GRG; GRG5; Amino enhancer of split
UniProt Entry Name
AES_HUMAN
NCBI Protein Information
amino-terminal enhancer of split; groucho-related protein 5; gp130-associated protein GAM

NCBI Summary for AES

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for AES

AES: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Belongs to the WD repeat Groucho/TLE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of growth; multicellular organismal development; cellular response to extracellular stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; skeletal development
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Research Articles on AES

1. AES binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone deficiency.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AES antibody

 Reference Product  PubMed Publications
 TLE1 antibody  >16 publications with AES and TLE1
 CTNNB1 antibody  >9 publications with AES and CTNNB1
 CCND1 antibody  >5 publications with AES and CCND1
 SIX3 antibody  >2 publications with AES and SIX3
 MYC antibody  >2 publications with AES and MYC
 HDAC1 antibody  >1 publications with AES and HDAC1
 LEF1 antibody  >1 publications with AES and LEF1
 HNF1A antibody  >1 publications with AES and HNF1A

Pathways associated with anti-AES antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram

Diseases associated with anti-AES antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >455 publications with AES and Brain Diseases
 Cardiovascular Diseases Antibodies  >450 publications with AES and Cardiovascular Diseases
 Hypertension Antibodies  >332 publications with AES and Hypertension
 Drug-Related Side Effects and Adverse Reactions Antibodies  >284 publications with AES and Drug-Related Side Effects and Adverse Reactions
 Liver Diseases Antibodies  >205 publications with AES and Liver Diseases
 Heart Diseases Antibodies  >169 publications with AES and Heart Diseases
 Kidney Diseases Antibodies  >154 publications with AES and Kidney Diseases
 Edema Antibodies  >145 publications with AES and Edema
 Inflammation Antibodies  >117 publications with AES and Inflammation
 Neoplasm Metastasis Antibodies  >110 publications with AES and Neoplasm Metastasis

Organs/Tissues associated with anti-AES antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1416 publications with AES and Blood
 Liver Antibodies  >395 publications with AES and Liver
 Skin Antibodies  >379 publications with AES and Skin
 Lung Antibodies  >309 publications with AES and Lung
 Bone Antibodies  >291 publications with AES and Bone
 Heart Antibodies  >286 publications with AES and Heart
 Brain Antibodies  >271 publications with AES and Brain
 Kidney Antibodies  >243 publications with AES and Kidney
 Vascular Antibodies  >227 publications with AES and Vascular
 Muscle Antibodies  >187 publications with AES and Muscle
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