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CLEC2A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150971

CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CLEC2A, Polyclonal Antibody
Full Product Name
CLEC2A Antibody
Product Gene Name
anti-CLEC2A antibody
Product Synonym Names
CLEC2A; KACL; PILAR; UNQ5792; KACL; UNQ5792/PRO19597; C-type lectin domain family 2 member A; Keratinocyte-associated C-type lectin; C-type lectin domain family 2, member A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
CLEC2A Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.
Preparation and Storage
CLEC2A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CLEC2A peptide (MBS152441) is used for blocking the activity of CLEC2A antibody (MBS150971)
Molecular Weight
18,576 Da
OMIM
612087
3D Structure
ModBase 3D Structure for Q6UVW9
Conjugate
Unconjugated
Immunogen
CLEC2A antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CLEC2A.
Buffer
CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CLEC2A antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CLEC2A antibody
CLEC2A antibody can be used for detection of CLEC2A by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CLEC2A antibody

Western blot analysis of CLEC2A in K562 cell lysate with CLEC2A antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-CLEC2A Polyclonal Antibody – Cat# MBS150971

Immunofluorescence (IF) of anti-CLEC2A antibody

Immunofluorescence of CLEC2A in K562 cells with CLEC2A antibody at 20 μg/mL.
Rabbit Anti-CLEC2A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150971

Other Notes

Small volumes of anti-CLEC2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC2A purchase

MBS150971 is an antibody targeting CLEC2A. Also known as CLEC2A Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC2A. It may not necessarily be applicable to this product.

NCBI GI #
195222725
NCBI GeneID
387836
NCBI Accession #
NP_001124183
UniProt Primary Accession #
Q6UVW9
UniProt Secondary Accession #
A5Y4G5; A9QKS2; A9QKS3
UniProt Related Accession #
Q6UVW9
GenBank Nucleotide #
NM_001130711.1
NCBI Official Full Name
C-type lectin domain family 2 member A isoform 1
NCBI Official Synonym Full Names
C-type lectin domain family 2, member A
NCBI Official Symbol
CLEC2A
NCBI Official Synonym Symbols
KACL; PILAR; UNQ5792; INPE5792
UniProt Protein Name
C-type lectin domain family 2 member A
UniProt Synonym Protein Names
Keratinocyte-associated C-type lectin; KACL; Proliferation-induced lymphocyte-associated receptor; PILAR
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC2A
UniProt Synonym Gene Names
KACL; KACL; PILAR
UniProt Entry Name
CLC2A_HUMAN
NCBI Protein Information
C-type lectin domain family 2 member A; keratinocyte-associated C-type lectin; proliferation-induced lymphocyte-associated receptor

NCBI Summary for CLEC2A

CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

UniProt Comments for CLEC2A

CLEC2A: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; carbohydrate binding

Biological Process: natural killer cell mediated cytotoxicity
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Research Articles on CLEC2A

1. CLEC-2, unlike platelet ITAM receptors, is not regulated by proteolysis and can be used to monitor platelet-derived microparticles

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CLEC2A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with CLEC2A and Inflammation
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