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TET3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151041

MBS151041 is an antibody targeting TET3. Also known as TET3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TET3, Polyclonal Antibody
Full Product Name
TET3 Antibody
Product Gene Name
anti-TET3 antibody
Product Synonym Names
TET3; hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; PBS containing 0.02% sodium azide.
Purity/Purification
TET3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of TET3 are known to exist. TET3 antibody is predicted to not cross react with other TET proteins.
Preparation and Storage
TET3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TET3 peptide (MBS152112) is used for blocking the activity of TET3 antibody (MBS151041)
Molecular Weight
183 kDa
OMIM
613555
3D Structure
ModBase 3D Structure for O43151
Conjugate
Unconjugated
Immunogen
TET3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TET3.
The immunogen is located within amino acids 1520-1570 of TET3
Applications Tested/Suitable for anti-TET3 antibody
ELISA, Immunofluorescence (IF), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB).

Western Blot (WB) of anti-TET3 antibody

Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-TET3 Polyclonal Antibody – Cat# MBS151041

Immunohistochemistry (IHC) of anti-TET3 antibody

Immunohistochemistry of TET3 in human brain tissue with TET3 antibody at 2.5 μg/ml.
Rabbit Anti-TET3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151041

Immunofluorescence (IF) of anti-TET3 antibody

Immunofluorescence of TET3 in human brain tissue with TET3 antibody at 20 μg/mL.
Rabbit Anti-TET3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151041

Other Notes

Small volumes of anti-TET3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.

NCBI GI #
149944516
NCBI GeneID
200424
NCBI Accession #
NP_001274420
UniProt Primary Accession #
O43151
UniProt Secondary Accession #
Q86Z24; Q8TBM9; A6NEI3
UniProt Related Accession #
O43151
GenBank Nucleotide #
NM_144993.1
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 3
NCBI Official Symbol
TET3
NCBI Official Synonym Symbols
hCG_40738
UniProt Protein Name
Methylcytosine dioxygenase TET3
Protein Family
Methylcytosine dioxygenase
UniProt Gene Name
TET3
UniProt Synonym Gene Names
KIAA0401
UniProt Entry Name
TET3_HUMAN
NCBI Protein Information
methylcytosine dioxygenase TET3

NCBI Summary for TET3

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

UniProt Comments for TET3

TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.14.11.n2

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: male pronucleus; cytoplasm; female pronucleus

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
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Research Articles on TET3

1. In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TET3 antibody

 Reference Product  PubMed Publications
 NANOG antibody  >5 publications with TET3 and NANOG

Pathways associated with anti-TET3 antibody

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram

Diseases associated with anti-TET3 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with TET3 and Kidney Diseases
 Adenocarcinoma Antibodies  >1 publications with TET3 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with TET3 and Cell Transformation, Neoplastic
 Adenoma Antibodies  >1 publications with TET3 and Adenoma
 Necrosis Antibodies  >1 publications with TET3 and Necrosis
 Intestinal Neoplasms Antibodies  >1 publications with TET3 and Intestinal Neoplasms
 Death Antibodies  >1 publications with TET3 and Death

Organs/Tissues associated with anti-TET3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with TET3 and Brain
 Embryonic Tissue Antibodies  >7 publications with TET3 and Embryonic Tissue
 Bone Antibodies  >5 publications with TET3 and Bone
 Liver Antibodies  >5 publications with TET3 and Liver
 Blood Antibodies  >4 publications with TET3 and Blood
 Prostate Antibodies  >2 publications with TET3 and Prostate
 Lung Antibodies  >2 publications with TET3 and Lung
 Pancreas Antibodies  >1 publications with TET3 and Pancreas
 Eye Antibodies  >1 publications with TET3 and Eye
 Testis Antibodies  >1 publications with TET3 and Testis
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