Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.

TET3 Blocking Peptide

Name: TET3 Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS152112
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS152112

MBS152112 is a blocking peptide targeting TET3. Also known as TET3 Peptide. More details

$210 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TET3, Blocking Peptide

Full Product Name

TET3 Peptide

Product Gene Name

TET3 blocking peptide

Product Synonym Names

hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3

Form/Format

Liquid

Concentration

200 ug/mL (lot specific)

Preparation and Storage

Store TET3 peptide at -20 degree C, stable for one year.

Antibody/Peptide Pairs

TET3 peptide (MBS152112) is used for blocking the activity of TET3 antibody (MBS151041)

Molecular Weight

77,471 Da

OMIM

613555

Species

Human

Buffer

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Location

17 amino acid peptide near the carboxy terminus of human TET3.

Applications Tested/Suitable for TET3 blocking peptide

Blocking (BL)

Application Notes for TET3 blocking peptide

TET3 peptide is used for blocking the activity of TET3 antibody.

Other Notes

Small volumes of TET3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.

NCBI GI #

149944516

NCBI GeneID

200424

NCBI Accession #

NP_659430

UniProt Primary Accession #

O43151

UniProt Secondary Accession #

Q86Z24; Q8TBM9; A6NEI3

UniProt Related Accession #

O43151

GenBank Nucleotide #

NM_144993.1

NCBI Official Synonym Full Names

tet methylcytosine dioxygenase 3

NCBI Official Symbol

TET3

NCBI Official Synonym Symbols

hCG_40738

UniProt Protein Name

Methylcytosine dioxygenase TET3

Protein Family

Methylcytosine dioxygenase

UniProt Gene Name

TET3

UniProt Synonym Gene Names

KIAA0401

UniProt Entry Name

TET3_HUMAN

NCBI Protein Information

methylcytosine dioxygenase TET3

NCBI Summary for TET3

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

UniProt Comments for TET3

TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: male pronucleus; cytoplasm; female pronucleus

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic

Research Articles on TET3

1. In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TET3 blocking peptide

Reference Product	PubMed Publications
NANOG blocking peptide	>5 publications with TET3 and NANOG

Pathways associated with TET3 blocking peptide

Products by Pathway	Pathway Diagram
Epigenetic Regulation Of Gene Expression Pathway antibodies	Epigenetic Regulation Of Gene Expression Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
TET1,2,3 And TDG Demethylate DNA Pathway antibodies	TET1,2,3 And TDG Demethylate DNA Pathway Diagram

Diseases associated with TET3 blocking peptide

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>2 publications with TET3 and Kidney Diseases
Adenocarcinoma Antibodies	>1 publications with TET3 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>1 publications with TET3 and Cell Transformation, Neoplastic
Adenoma Antibodies	>1 publications with TET3 and Adenoma
Necrosis Antibodies	>1 publications with TET3 and Necrosis
Intestinal Neoplasms Antibodies	>1 publications with TET3 and Intestinal Neoplasms
Death Antibodies	>1 publications with TET3 and Death

Organs/Tissues associated with TET3 blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>17 publications with TET3 and Brain
Embryonic Tissue Antibodies	>7 publications with TET3 and Embryonic Tissue
Bone Antibodies	>5 publications with TET3 and Bone
Liver Antibodies	>5 publications with TET3 and Liver
Blood Antibodies	>4 publications with TET3 and Blood
Prostate Antibodies	>2 publications with TET3 and Prostate
Lung Antibodies	>2 publications with TET3 and Lung
Pancreas Antibodies	>1 publications with TET3 and Pancreas
Eye Antibodies	>1 publications with TET3 and Eye
Testis Antibodies	>1 publications with TET3 and Testis