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CDCA8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151409

CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CDCA8, Polyclonal Antibody
Full Product Name
CDCA8 Antibody
Product Gene Name
anti-CDCA8 antibody
Product Synonym Names
CDCA8; BOR; DasraB; MESRGP; BOREALIN; PESCRG3; Borealin; Cell division cycle-associated protein 8; hDasra-B; cell division cycle associated 8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
CDCA8 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
CDCA8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CDCA8 peptide (MBS152863) is used for blocking the activity of CDCA8 antibody (MBS151409)
Molecular Weight
31,323 Da
OMIM
609977
3D Structure
ModBase 3D Structure for Q53HL2
Conjugate
Unconjugated
Immunogen
CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8.
Buffer
CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CDCA8 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CDCA8 antibody
CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 mug/mL. Antibody can also be used for immunoflourescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CDCA8 antibody

Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-CDCA8 Polyclonal Antibody – Cat# MBS151409

Immunofluorescence (IF) of anti-CDCA8 antibody

Immunofluorescence of CDCA8 in rat kidney tissue with CDCA8 antibody at 20 μg/mL.
Rabbit Anti-CDCA8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151409

Immunofluorescence (IF) of anti-CDCA8 antibody

Immunofluorescence of CDCA8 in Rat Kidney cells with CDCA8 antibody at 20 μg/mL.
Rabbit Anti-CDCA8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151409

Other Notes

Small volumes of anti-CDCA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDCA8 purchase

MBS151409 is an antibody targeting CDCA8. Also known as CDCA8 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.

NCBI GI #
8922438
NCBI GeneID
55143
NCBI Accession #
NP_060571
UniProt Primary Accession #
Q53HL2
UniProt Secondary Accession #
Q53HN1; Q96AM3; Q9NVW5; D3DPT4
UniProt Related Accession #
Q53HL2
GenBank Nucleotide #
NM_018101.3
NCBI Official Full Name
borealin
NCBI Official Synonym Full Names
cell division cycle associated 8
NCBI Official Symbol
CDCA8
NCBI Official Synonym Symbols
BOR; DasraB; MESRGP; BOREALIN
UniProt Protein Name
Borealin
UniProt Synonym Protein Names
Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein
UniProt Gene Name
CDCA8
UniProt Synonym Gene Names
PESCRG3; hDasra-B
UniProt Entry Name
BOREA_HUMAN
NCBI Protein Information
borealin; Dasra B; dasra-B; hDasra-B; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein

NCBI Summary for CDCA8

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
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UniProt Comments for CDCA8

Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Cell cycle regulation; Nucleolus

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: intercellular bridge; protein complex; nucleolus; spindle; midbody; nucleus; cytosol; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: cell division; mitotic cell cycle; mitotic metaphase plate congression; chromosome organization and biogenesis
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Research Articles on CDCA8

1. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDCA8 antibody

 Reference Product  PubMed Publications
 BIRC5 antibody  >26 publications with CDCA8 and BIRC5
 INCENP antibody  >24 publications with CDCA8 and INCENP
 AURKB antibody  >24 publications with CDCA8 and AURKB
 KIF2C antibody  >3 publications with CDCA8 and KIF2C
 CENPF antibody  >1 publications with CDCA8 and CENPF
 KIF20A antibody  >1 publications with CDCA8 and KIF20A
 PLK1 antibody  >1 publications with CDCA8 and PLK1
 CDC20 antibody  >1 publications with CDCA8 and CDC20

Pathways associated with anti-CDCA8 antibody

 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-CDCA8 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >2 publications with CDCA8 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CDCA8 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >2 publications with CDCA8 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >2 publications with CDCA8 and Lung Neoplasms
 Anemia Antibodies  >1 publications with CDCA8 and Anemia
 Adenocarcinoma Antibodies  >1 publications with CDCA8 and Adenocarcinoma
 Uterine Cervical Neoplasms Antibodies  >1 publications with CDCA8 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-CDCA8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with CDCA8 and Blood
 Lung Antibodies  >2 publications with CDCA8 and Lung
 Stomach Antibodies  >2 publications with CDCA8 and Stomach
 Uterus Antibodies  >2 publications with CDCA8 and Uterus
 Embryonic Tissue Antibodies  >2 publications with CDCA8 and Embryonic Tissue
 Bone Antibodies  >1 publications with CDCA8 and Bone
 Cervix Antibodies  >1 publications with CDCA8 and Cervix
 Vascular Antibodies  >1 publications with CDCA8 and Vascular
 Bone Marrow Antibodies  >1 publications with CDCA8 and Bone Marrow
 Spleen Antibodies  >1 publications with CDCA8 and Spleen
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