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CCL4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153358

CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal… More details

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Product Overview

Online Datasheet in PDF
Product Name
CCL4, Polyclonal Antibody
Full Product Name
CCL4 Antibody
Product Gene Name
anti-CCL4 antibody
Product Synonym Names
CCL4; ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; chemokine (C-C motif) ligand 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
CCL4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
CCL4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
CCL4 peptide (MBS154164) is used for blocking the activity of CCL4 antibody (MBS153358)
Molecular Weight
Predicted: 10 kDa
OMIM
182284
3D Structure
ModBase 3D Structure for P13236
Conjugate
Unconjugated
Immunogen
Rabbit polyclonal CCL4 antibody was raised against a 15 amino acid peptide near the center of human CCL4.
Buffer
CCL4 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CCL4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CCL4 antibody
CCL4 antibody can be used for detection of CCL4 by Western blot at 1 - 2 ug/mL.
Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-CCL4 antibody

Western blot analysis of CCL4 in rat brain tissue lysate with CCL4 antibody at 1 μg/mL.
Rabbit Anti-CCL4 Polyclonal Antibody – Cat# MBS153358

Immunohistochemistry (IHC) of anti-CCL4 antibody

Immunohistochemistry of CCL4 in rat brain tissue with CCL4 antibody at 2.5 μg/ml.
Rabbit Anti-CCL4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153358

Immunofluorescence (IF) of anti-CCL4 antibody

Immunofluorescence of CCL4 in rat brain tissue with CCL4 antibody at 20 μg/ml.
Rabbit Anti-CCL4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153358

Other Notes

Small volumes of anti-CCL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL4 purchase

MBS153358 is an antibody targeting CCL4. Also known as CCL4 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL4. It may not necessarily be applicable to this product.

NCBI GI #
4506845
NCBI GeneID
6351
NCBI Accession #
NP_002975
UniProt Primary Accession #
P13236
UniProt Secondary Accession #
P22617; Q13704; Q3SXL8; Q6FGI8
UniProt Related Accession #
P13236
GenBank Nucleotide #
NM_002984.3
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 4
NCBI Official Symbol
CCL4
NCBI Official Synonym Symbols
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL4
UniProt Synonym Gene Names
LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2
UniProt Entry Name
CCL4_HUMAN
NCBI Protein Information
C-C motif chemokine 4; PAT 744; SIS-gamma; MIP-1-beta(1-69); secreted protein G-26; T-cell activation protein 2; G-26 T-lymphocyte-secreted protein; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; small inducible cytokine A4 (homologous to mouse Mip-1b)

NCBI Summary for CCL4

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

UniProt Comments for CCL4

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; cell adhesion; signal transduction; inflammatory response; positive regulation of calcium ion transport; cell motility
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Research Articles on CCL4

1. The allele and genotype frequencies of CCL2, CCL3 and CCL4 were not different between HCs and patients with PTB.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL4 antibody

 Reference Product  PubMed Publications
 CCL3 antibody  >1613 publications with CCL4 and CCL3
 CCR5 antibody  >591 publications with CCL4 and CCR5
 CCR1 antibody  >197 publications with CCL4 and CCR1
 CXCL2 antibody  >187 publications with CCL4 and CXCL2
 CCR2 antibody  >108 publications with CCL4 and CCR2
 CXCR3 antibody  >75 publications with CCL4 and CXCR3
 CCR3 antibody  >71 publications with CCL4 and CCR3
 CCR7 antibody  >53 publications with CCL4 and CCR7
 CCR8 antibody  >24 publications with CCL4 and CCR8
 IL1B antibody  >15 publications with CCL4 and IL1B

Pathways associated with anti-CCL4 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-CCL4 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >692 publications with CCL4 and Immune System Diseases
 Protein Deficiency Antibodies  >158 publications with CCL4 and Protein Deficiency
 Bone Diseases Antibodies  >107 publications with CCL4 and Bone Diseases
 Hypertension, Portal Antibodies  >90 publications with CCL4 and Hypertension, Portal
 Disease Susceptibility Antibodies  >77 publications with CCL4 and Disease Susceptibility
 Gastrointestinal Diseases Antibodies  >76 publications with CCL4 and Gastrointestinal Diseases
 Eye Diseases Antibodies  >72 publications with CCL4 and Eye Diseases
 Pneumonia Antibodies  >68 publications with CCL4 and Pneumonia
 Ischemia Antibodies  >61 publications with CCL4 and Ischemia
 Diabetes Mellitus Antibodies  >50 publications with CCL4 and Diabetes Mellitus

Organs/Tissues associated with anti-CCL4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4340 publications with CCL4 and Liver
 Blood Antibodies  >3256 publications with CCL4 and Blood
 Lung Antibodies  >401 publications with CCL4 and Lung
 Bone Marrow Antibodies  >299 publications with CCL4 and Bone Marrow
 Kidney Antibodies  >284 publications with CCL4 and Kidney
 Intestine Antibodies  >117 publications with CCL4 and Intestine
 Lymph Antibodies  >109 publications with CCL4 and Lymph
 Parathyroid Antibodies  >14 publications with CCL4 and Parathyroid
 Prostate Antibodies  >11 publications with CCL4 and Prostate
 Adrenal Gland Antibodies  >7 publications with CCL4 and Adrenal Gland
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