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PLA1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153483

PLA1A Antibody: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic… More details

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Product Overview

Online Datasheet in PDF
Product Name
PLA1A, Polyclonal Antibody
Full Product Name
PLA1A Antibody
Product Gene Name
anti-PLA1A antibody
Product Synonym Names
PLA1A; PSPLA1; PS-PLA1; NMD; PSPLA1; Phospholipase A1 member A; Phosphatidylserine-specific phospholipase A1; phospholipase A1 member A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
PLA1A Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of PLA1A are known to exist; this antibody will detect all three isoforms.
Preparation and Storage
PLA1A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
PLA1A peptide (MBS153787) is used for blocking the activity of PLA1A antibody (MBS153483)
Molecular Weight
50 kDa
OMIM
607460
3D Structure
ModBase 3D Structure for Q53H76
Conjugate
Unconjugated
Immunogen
PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A.
Buffer
PLA1A Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-PLA1A antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PLA1A antibody
PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-PLA1A antibody

Western blot analysis of PLA1A in human kidney tissue lysate with PLA1A antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-PLA1A Polyclonal Antibody – Cat# MBS153483

Immunofluorescence (IF) of anti-PLA1A antibody

Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 μg/mL.
Rabbit Anti-PLA1A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153483

Other Notes

Small volumes of anti-PLA1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLA1A purchase

MBS153483 is an antibody targeting PLA1A. Also known as PLA1A Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA1A. It may not necessarily be applicable to this product.

NCBI GI #
7706661
NCBI GeneID
51365
NCBI Accession #
NP_056984
UniProt Primary Accession #
Q53H76
UniProt Secondary Accession #
O95991; Q86WX6; Q9UPD2; B2R8V2; B4DXA2
UniProt Related Accession #
Q53H76
GenBank Nucleotide #
NM_015900.3
NCBI Official Full Name
phospholipase A1 member A isoform 1
NCBI Official Synonym Full Names
phospholipase A1 member A
NCBI Official Symbol
PLA1A
NCBI Official Synonym Symbols
PSPLA1; PS-PLA1
UniProt Protein Name
Phospholipase A1 member A
UniProt Synonym Protein Names
Phosphatidylserine-specific phospholipase A1; PS-PLA1
Protein Family
Phospholipase
UniProt Gene Name
PLA1A
UniProt Synonym Gene Names
NMD; PSPLA1; PS-PLA1
UniProt Entry Name
PLA1A_HUMAN
NCBI Protein Information
phospholipase A1 member A; phosphatidylserine-specific phospholipase A1alpha

NCBI Summary for PLA1A

The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
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UniProt Comments for PLA1A

PLA1A: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Belongs to the AB hydrolase superfamily. Lipase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Phospholipase; Secreted, signal peptide; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 3q13.13-q13.2

Cellular Component: acrosomal membrane

Molecular Function: phospholipase A1 activity

Biological Process: phosphatidylserine metabolic process; lipid metabolic process; lipid catabolic process
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Research Articles on PLA1A

1. PLA1A2 polymorphism is associated with mortality in participants whose hemoglobin A1c ranges from 5.5% to 6.5%.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLA1A antibody

 Products by Pathway  Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram

Diseases associated with anti-PLA1A antibody

 Disease Name  Pubmed Publications
 Hypertriglyceridemia Antibodies  >2 publications with PLA1A and Hypertriglyceridemia
 Necrosis Antibodies  >2 publications with PLA1A and Necrosis
 Dyslipidemias Antibodies  >1 publications with PLA1A and Dyslipidemias
 Hepatitis Antibodies  >1 publications with PLA1A and Hepatitis
 Fibrosis Antibodies  >1 publications with PLA1A and Fibrosis
 Fatty Liver Antibodies  >1 publications with PLA1A and Fatty Liver
 Inflammation Antibodies  >1 publications with PLA1A and Inflammation

Organs/Tissues associated with anti-PLA1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with PLA1A and Blood
 Heart Antibodies  >1 publications with PLA1A and Heart
 Prostate Antibodies  >1 publications with PLA1A and Prostate
 Liver Antibodies  >1 publications with PLA1A and Liver
 Skin Antibodies  >1 publications with PLA1A and Skin
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