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TICRR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153502

TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42 More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TICRR, Polyclonal Antibody
Full Product Name
TICRR Antibody
Product Gene Name
anti-TICRR antibody
Product Synonym Names
TICRR; SLD3; Treslin; C15orf42; TopBP1-interacting checkpoint and replication regulator; TOPBP1-interacting checkpoint and replication regulator
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
TICRR antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.
Preparation and Storage
TICRR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
TICRR peptide (MBS153886) is used for blocking the activity of TICRR antibody (MBS153502)
Molecular Weight
Predicted: 210 kDa

Observed: 220 kDa
OMIM
613298
3D Structure
ModBase 3D Structure for Q7Z2Z1
Conjugate
Unconjugated
Immunogen
TICRR antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TICRR.
Buffer
TICRR antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TICRR antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TICRR antibody
TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL.

Western Blot (WB) of anti-TICRR antibody

Western blot analysis of TICRR in human small intestine tissue lysate with TICRR antibody at 1 μg/ml.
Rabbit Anti-TICRR Polyclonal Antibody – Cat# MBS153502

Immunohistochemistry (IHC) of anti-TICRR antibody

Immunohistochemistry of TICRR in human small intestine tissue with TICRR antibody at 5 μg/mL.
Rabbit Anti-TICRR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153502

Immunofluorescence (IF) of anti-TICRR antibody

Immunofluorescence of TICRR in human small intestine tissue with TICRR antibody at 20 μg/mL.
Rabbit Anti-TICRR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153502

Other Notes

Small volumes of anti-TICRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TICRR purchase

MBS153502 is an antibody targeting TICRR. Also known as TICRR Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TICRR. It may not necessarily be applicable to this product.

NCBI GI #
118421085
NCBI GeneID
90381
NCBI Accession #
NP_689472
UniProt Primary Accession #
Q7Z2Z1
UniProt Secondary Accession #
Q8N4X8; Q8NCH6; Q9BU55; B2RE07; B3KVV9; D3IUT4
UniProt Related Accession #
Q7Z2Z1
GenBank Nucleotide #
NM_152259.3
NCBI Official Full Name
treslin
NCBI Official Synonym Full Names
TOPBP1-interacting checkpoint and replication regulator
NCBI Official Symbol
TICRR
NCBI Official Synonym Symbols
SLD3; Treslin; C15orf42
UniProt Protein Name
Treslin
UniProt Synonym Protein Names
TopBP1-interacting checkpoint and replication regulator; TopBP1-interacting, replication-stimulating protein
Protein Family
Treslin
UniProt Gene Name
TICRR
UniProt Synonym Gene Names
C15orf42
UniProt Entry Name
TICRR_HUMAN
NCBI Protein Information
treslin; SLD3 homolog; topBP1-interacting replication-stimulating protein; topBP1-interacting, replication-stimulating protein

NCBI Summary for TICRR

Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

UniProt Comments for TICRR

TICRR: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Belongs to the treslin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication; Cell cycle regulation

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; chromatin binding

Biological Process: regulation of DNA replication initiation; mitotic cell cycle DNA replication checkpoint; response to ionizing radiation; DNA repair; DNA replication; cell cycle checkpoint; formation of translation preinitiation complex
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Research Articles on TICRR

1. Treslin is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TICRR antibody

 Reference Product  PubMed Publications
 TOPBP1 antibody  >8 publications with TICRR and TOPBP1
 CDC45 antibody  >3 publications with TICRR and CDC45
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