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Natalizumab Antibody – Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS156066

Natalizumab is a recombinant, humanized monoclonal antibody, binds to alpha4beta1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1).Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Natalizumab, Monoclonal Antibody
Full Product Name
Natalizumab, Humanized antibody
Product Synonym Names
AN 100226; BG00002; ITGA4; CD49d
Clonality
Monoclonal
Isotype
IgG4-kappa
Species Reactivity
Human
Form/Format
PBS buffer PH7.5
Concentration
0.43 mg/ml (lot specific)
Specificity
ITGA4/CD49d[Homo Sapiens]
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
CAS Number
189261-10-7
Species
Humanized
Activity in Vitro
Natalizumab, a recombinant, humanized antibody, binds to ?4?1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between ?4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.

Product Categories/Family for anti-Natalizumab antibody

Antibody drug analogues
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of anti-Natalizumab antibody

Anti-Natalizumab Monoclonal Antibody – Cat# MBS156066

Other Notes

Small volumes of anti-Natalizumab antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Natalizumab purchase

MBS156066 is an antibody targeting Natalizumab. Also known as Natalizumab, Humanized antibody. Reactive in Human.
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