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TBR1 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750096

Probable transcriptional regulator involved in developmental processes. Required for normal brain development. More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TBR1, Monoclonal Antibody
Full Product Name
Anti-TBR1 Rabbit Monoclonal Antibody
Product Gene Name
anti-TBR1 antibody
Product Synonym Names
T-box brain protein 1; T-brain-1; TBR-1; TES-56; TBR1
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
74053 MW
OMIM
U49250 mRNA
3D Structure
ModBase 3D Structure for Q16650
Immunogen
A synthesized peptide derived from human TBR1
Subcellular Localization
Nucleus.
Tissue Specificity
Brain.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Categories/Family for anti-TBR1 antibody

Neuroscience; Neurology Process; Neural Signal Transduction; Neuroscience; neurogenesis
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TBR1 antibody
Western Blot (WB)
Application Notes for anti-TBR1 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-TBR1 antibody

Western blot analysis of TBR1 expression in human fetal brain lysate (MBS1750096).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TBR1 monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for TBR1
Rabbit Anti-TBR1 Monoclonal Antibody – Cat# MBS1750096

Other Notes

Small volumes of anti-TBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBR1 purchase

MBS1750096 is an antibody targeting TBR1. Also known as Anti-TBR1 Rabbit Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBR1. It may not necessarily be applicable to this product.

NCBI GI #
5730081
NCBI GeneID
10716
NCBI Accession #
NP_006584.1
UniProt Primary Accession #
Q16650
UniProt Secondary Accession #
Q14DC5; Q53TH0; Q56A81; B0AZS4; B2R6G5
UniProt Related Accession #
Q16650
GenBank Nucleotide #
NM_006593.3
NCBI Official Full Name
T-box brain protein 1
NCBI Official Synonym Full Names
T-box, brain 1
NCBI Official Symbol
TBR1
NCBI Official Synonym Symbols
TBR-1; TES-56
UniProt Protein Name
T-box brain protein 1
UniProt Synonym Protein Names
TES-56
Protein Family
T-box brain protein
UniProt Gene Name
TBR1
UniProt Synonym Gene Names
T-brain-1; TBR-1
NCBI Protein Information
T-box brain protein 1

NCBI Summary for TBR1

This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]
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Research Articles on TBR1

1. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBR1 antibody

 Reference Product  PubMed Publications
 FEZF2 antibody  >9 publications with TBR1 and FEZF2
 CASK antibody  >7 publications with TBR1 and CASK
 CALB2 antibody  >6 publications with TBR1 and CALB2
 EMX1 antibody  >6 publications with TBR1 and EMX1
 NKX2-1 antibody  >5 publications with TBR1 and NKX2-1
 EMX2 antibody  >4 publications with TBR1 and EMX2
 NEUROD1 antibody  >4 publications with TBR1 and NEUROD1
 RELN antibody  >4 publications with TBR1 and RELN
 GSX2 antibody  >1 publications with TBR1 and GSX2

Diseases associated with anti-TBR1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >14 publications with TBR1 and Congenital Abnormalities
 Neurobehavioral Manifestations Antibodies  >6 publications with TBR1 and Neurobehavioral Manifestations
 Cognition Disorders Antibodies  >6 publications with TBR1 and Cognition Disorders
 Abnormalities, Multiple Antibodies  >2 publications with TBR1 and Abnormalities, Multiple
 Skin Diseases Antibodies  >2 publications with TBR1 and Skin Diseases
 Inflammation Antibodies  >2 publications with TBR1 and Inflammation
 Learning Disorders Antibodies  >1 publications with TBR1 and Learning Disorders
 Skin Abnormalities Antibodies  >1 publications with TBR1 and Skin Abnormalities
 Glioblastoma Antibodies  >1 publications with TBR1 and Glioblastoma
 Fibrosis Antibodies  >1 publications with TBR1 and Fibrosis

Organs/Tissues associated with anti-TBR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >122 publications with TBR1 and Brain
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