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BCAT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175211

Description: Rabbit IgG polyclonal antibody for Branched-chain-amino-acid aminotransferase, cytosolic(BCAT1) detection. Tested with WB, IHC-P in Human.Background: BCAT1, Branched-chain Aminotransferase1, is also know as BCT1. The BCAT1 gene is highly… More details

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Product Overview

Online Datasheet in PDF
Product Name
BCAT1, Polyclonal Antibody
Full Product Name
Anti-BCAT1 antibody
Product Gene Name
anti-BCAT1 antibody
Product Synonym Names
Branched-chain-amino-acid aminotransferase, cytosolic(BCAT(c)); branched chain amino-acid transaminase 1, cytosolic; BCAT antibody; BCAT(c) antibody; Bcat1 antibody; BCAT1_HUMAN antibody; BCT1 antibody; Branched chain amino acid aminotransferase, cytosolic antibody; branched chain amino-acid transaminase 1, cytosolic antibody; branched chain aminotransferase 1 antibody; branched chain aminotransferase 1, cytosolic antibody; Branched-chain-amino-acid aminotransferase antibody; cytosolic antibody; DKFZp686E12175 antibody; EC 2.6.1.42 antibody; ECA39 antibody; MECA39 antibody; placental protein 18 antibody; PNAS 121 antibody; PP18 antibody; Protein ECA39 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
44,131 Da
OMIM
113520
3D Structure
ModBase 3D Structure for P54687
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human BCAT1 (360-375aa KLASRILSKLTDIQYGR), different from the related mouse sequence by one amino acid, rat sequence by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-BCAT1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-BCAT1 antibody

Anti-BCAT1 antibody, MBS175211, Western blotting
All lanes: Anti BCAT1 (MBS175211) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 45KD
Observed bind size: 45KD
Rabbit Anti-BCAT1 Polyclonal Antibody – Cat# MBS175211

Immunohistochemistry (IHC) of anti-BCAT1 antibody

Anti-BCAT1 antibody, MBS175211, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-BCAT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175211

Other Notes

Small volumes of anti-BCAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAT1 purchase

MBS175211 is an antibody targeting BCAT1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAT1. It may not necessarily be applicable to this product.

NCBI GI #
215274162
NCBI GeneID
586
NCBI Accession #
P54687.3
UniProt Primary Accession #
P54687
UniProt Secondary Accession #
Q68DQ7; Q96MY9; B3KY27; B7Z2M5; B7Z5L0; F5H5E4
UniProt Related Accession #
P54687
NCBI Official Full Name
Branched-chain-amino-acid aminotransferase, cytosolic
NCBI Official Synonym Full Names
branched chain amino-acid transaminase 1, cytosolic
NCBI Official Symbol
BCAT1
NCBI Official Synonym Symbols
BCT1; PP18; BCATC; ECA39; MECA39; PNAS121
UniProt Protein Name
Branched-chain-amino-acid aminotransferase, cytosolic
UniProt Synonym Protein Names
Protein ECA39
Protein Family
Branched-chain-amino-acid aminotransferase
UniProt Gene Name
BCAT1
UniProt Synonym Gene Names
BCT1; ECA39; BCAT(c)
UniProt Entry Name
BCAT1_HUMAN
NCBI Protein Information
branched-chain-amino-acid aminotransferase, cytosolic; placental protein 18; branched chain aminotransferase 1, cytosolic

NCBI Summary for BCAT1

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
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UniProt Comments for BCAT1

BCAT1: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.6.1.42

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: mitochondrion; cytosol

Molecular Function: identical protein binding; branched-chain-amino-acid transaminase activity

Biological Process: cell proliferation; branched chain family amino acid catabolic process; G1/S transition of mitotic cell cycle; branched chain family amino acid biosynthetic process
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Research Articles on BCAT1

1. levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 and RPL11 cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAT1 antibody

 Reference Product  PubMed Publications
 MYC antibody  >13 publications with BCAT1 and MYC
 MAX antibody  >2 publications with BCAT1 and MAX

Pathways associated with anti-BCAT1 antibody

 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway antibodies  Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway Diagram
 Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway antibodies  Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with anti-BCAT1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >5 publications with BCAT1 and Brain Diseases
 Liver Diseases Antibodies  >3 publications with BCAT1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >3 publications with BCAT1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >3 publications with BCAT1 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with BCAT1 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with BCAT1 and Breast Neoplasms
 Fatty Liver Antibodies  >2 publications with BCAT1 and Fatty Liver
 Adenocarcinoma Antibodies  >2 publications with BCAT1 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >2 publications with BCAT1 and Ovarian Neoplasms
 Hypertension Antibodies  >1 publications with BCAT1 and Hypertension

Organs/Tissues associated with anti-BCAT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with BCAT1 and Blood
 Brain Antibodies  >9 publications with BCAT1 and Brain
 Liver Antibodies  >5 publications with BCAT1 and Liver
 Vascular Antibodies  >5 publications with BCAT1 and Vascular
 Heart Antibodies  >4 publications with BCAT1 and Heart
 Muscle Antibodies  >4 publications with BCAT1 and Muscle
 Connective Tissue Antibodies  >2 publications with BCAT1 and Connective Tissue
 Testis Antibodies  >2 publications with BCAT1 and Testis
 Ovary Antibodies  >1 publications with BCAT1 and Ovary
 Bone Antibodies  >1 publications with BCAT1 and Bone
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