Rabbit Anti-MALT1 Monoclonal Antibody – Cat# MBS1752110

Figure 1. Western blot analysis of MALT1 using anti-MALT1 antibody (M01599-1).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MALT1 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for MALT1.

MALT1 Antibody – Rabbit Monoclonal

Name: MALT1 Antibody; Monoclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1752110
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752110

Rabbit IgG Monoclonal antibody for Q9UDY8 detection. Tested positive for WB IF/IF FC in Human More details

$210 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MALT1, Monoclonal Antibody

Full Product Name

Anti-MALT1 Monoclonal Antibody

Product Gene Name

anti-MALT1 antibody

Clonality

Monoclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-Chromatography

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.

Molecular Weight

91,081 Da

3D Structure

ModBase 3D Structure for Q9UDY8

Immunogen

A synthesized peptide derived from human MALT1 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-MALT1 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB)

Application Notes for anti-MALT1 antibody

WB: 1:500-1:2000
ICC/IF: 1:50-1:200
FC/FACS: 1:60

Other Notes

Small volumes of anti-MALT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MALT1 purchase

MBS1752110 is an antibody targeting MALT1. Also known as Anti-MALT1 Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MALT1. It may not necessarily be applicable to this product.

NCBI GI #

5803078

NCBI GeneID

10892

NCBI Accession #

NP_006776.1

UniProt Primary Accession #

Q9UDY8

UniProt Secondary Accession #

Q9NTB7; Q9ULX4

UniProt Related Accession #

Q9UDY8

GenBank Nucleotide #

NM_006785.4

NCBI Official Full Name

mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a

NCBI Official Synonym Full Names

MALT1 paracaspase

NCBI Official Symbol

MALT1

NCBI Official Synonym Symbols

MLT; MLT1; IMD12; PCASP1

UniProt Protein Name

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

UniProt Synonym Protein Names

MALT lymphoma-associated translocation; Paracaspase

Protein Family

Mucosa-associated lymphoid tissue lymphoma translocation protein

UniProt Gene Name

MALT1

UniProt Synonym Gene Names

MLT

NCBI Protein Information

mucosa-associated lymphoid tissue lymphoma translocation protein 1

NCBI Summary for MALT1

This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

UniProt Comments for MALT1

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation ().

Research Articles on MALT1

1. MALT1 and TRAF6 cooperatively interact with CARMA1-BCL10 filaments and form CARMA1-BCL10-MALT1-TRAF6 signalosome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MALT1 antibody

Reference Product	PubMed Publications
BCL10 antibody	>195 publications with MALT1 and BCL10
TRAF6 antibody	>15 publications with MALT1 and TRAF6
TRAF2 antibody	>15 publications with MALT1 and TRAF2
SQSTM1 antibody	>1 publications with MALT1 and SQSTM1

Pathways associated with anti-MALT1 antibody

Products by Pathway	Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Canonical NF-kappaB Pathway antibodies	Canonical NF-kappaB Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream TCR Signaling Pathway antibodies	Downstream TCR Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram

Diseases associated with anti-MALT1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>300 publications with MALT1 and Neoplasms
Immune System Diseases Antibodies	>289 publications with MALT1 and Immune System Diseases
Lymphoma, Large B-Cell, Diffuse Antibodies	>73 publications with MALT1 and Lymphoma, Large B-Cell, Diffuse
Inflammation Antibodies	>30 publications with MALT1 and Inflammation
Lung Neoplasms Antibodies	>23 publications with MALT1 and Lung Neoplasms
Skin Diseases Antibodies	>20 publications with MALT1 and Skin Diseases
Necrosis Antibodies	>17 publications with MALT1 and Necrosis
Autoimmune Diseases Antibodies	>16 publications with MALT1 and Autoimmune Diseases
Skin Neoplasms Antibodies	>15 publications with MALT1 and Skin Neoplasms
Cell Transformation, Neoplastic Antibodies	>15 publications with MALT1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-MALT1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>109 publications with MALT1 and Blood
Stomach Antibodies	>80 publications with MALT1 and Stomach
Lung Antibodies	>35 publications with MALT1 and Lung
Lymph Node Antibodies	>18 publications with MALT1 and Lymph Node
Intestine Antibodies	>17 publications with MALT1 and Intestine
Liver Antibodies	>14 publications with MALT1 and Liver
Eye Antibodies	>12 publications with MALT1 and Eye
Bone Antibodies	>10 publications with MALT1 and Bone
Thymus Antibodies	>9 publications with MALT1 and Thymus
Vascular Antibodies	>6 publications with MALT1 and Vascular