• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MCM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175236

Description: Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM2(MCM2) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.Background: MCM2(MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 2),also known as MITOTIN, CDCL1 or… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MCM2, Polyclonal Antibody
Full Product Name
Anti-MCM2 antibody
Product Gene Name
anti-MCM2 antibody
Product Synonym Names
DNA replication licensing factor MCM2; minichromosome maintenance complex component 2; BM28 antibody; CCNL 1 antibody; CCNL1 antibody; CDC like 1 antibody; CDC like-1 antibody; cdc19 antibody; CDCL 1 antibody; CDCL1 antibody; Cell devision cycle like 1 antibody; Cyclin like 1 antibody; cyclin like-1 antibody; D3S3194 antibody; DNA replication licensing factor MCM2 antibody; KIAA0030 antibody; MCM 2 antibody; MCM2 antibody; MCM2 minichromosome maintenance deficient 2 mitotin antibody; MCM2 minichromosome maintenance deficient 2 mitotin(S. cerevisiae) antibody; MCM2 minichromosome maintenance deficient 2, mitotin antibody; MCM2_HUMAN antibody; MGC10606 antibody; Minichromosome maintenance complex component 2 antibody; Minichromosome maintenance deficient 2(mitotin) antibody; Minichromosome maintenance deficient 2 mitotin antibody; Minichromosome maintenance protein 2 antibody; Minichromosome maintenance protein 2 homolog antibody; Mitotin antibody; Nuclear protein BM28 antibody; OTTHUMP00000216047 antibody; OTTHUMP00000216050 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
101,896 Da
OMIM
116945
3D Structure
ModBase 3D Structure for P49736
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MCM2 (889-904aa NKFSHDLKRKMILQQF), different from the related rat and mouse sequences by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-MCM2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Western Blot (WB) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175236, Western blotting
Lane 1: SW620 Cell Lysate
Lane 2: PANC Cell Lysate
Lane 3: JURKAT Cell Lysate
Lane 4: HELA Cell Lysate
Rabbit Anti-MCM2 Polyclonal Antibody – Cat# MBS175236

Immunohistochemistry (IHC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175236, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175236

Immunohistochemistry (IHC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175236, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175236

Immunocytochemistry (ICC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175236, ICC
ICC: A549 Cell
Rabbit Anti-MCM2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175236

Other Notes

Small volumes of anti-MCM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCM2 purchase

MBS175236 is an antibody targeting MCM2. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM2. It may not necessarily be applicable to this product.

NCBI GI #
41019490
NCBI GeneID
4171
NCBI Accession #
P49736.4
UniProt Primary Accession #
P49736
UniProt Secondary Accession #
Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7
UniProt Related Accession #
P49736
NCBI Official Full Name
DNA replication licensing factor MCM2
NCBI Official Synonym Full Names
minichromosome maintenance complex component 2
NCBI Official Symbol
MCM2
NCBI Official Synonym Symbols
BM28; CCNL1; CDCL1; cdc19; D3S3194; MITOTIN
UniProt Protein Name
DNA replication licensing factor MCM2
UniProt Synonym Protein Names
Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Protein Family
DNA replication licensing factor
UniProt Gene Name
MCM2
UniProt Synonym Gene Names
BM28; CCNL1; CDCL1; KIAA0030
UniProt Entry Name
MCM2_HUMAN
NCBI Protein Information
DNA replication licensing factor MCM2; cyclin-like 1; nuclear protein BM28; cell devision cycle-like 1; minichromosome maintenance protein 2 homolog; minichromosome maintenance deficient 2 (mitotin); MCM2 minichromosome maintenance deficient 2, mitotin

NCBI Summary for MCM2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Show more

UniProt Comments for MCM2

MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: microtubule cytoskeleton; nucleoplasm; MCM complex; cytoplasm; nuclear origin of replication recognition complex; nucleus; chromatin

Molecular Function: protein binding; DNA helicase activity; DNA binding; histone binding; metal ion binding; DNA replication origin binding; ATP binding

Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; cell cycle; G1/S transition of mitotic cell cycle
Show more

Research Articles on MCM2

1. ORC/Cdc6/MCM2-7 complex is a new regulatory mechanism for the helicase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCM2 antibody

 Reference Product  PubMed Publications
 MCM7 antibody  >106 publications with MCM2 and MCM7
 MCM4 antibody  >101 publications with MCM2 and MCM4
 MCM3 antibody  >90 publications with MCM2 and MCM3
 CDC45 antibody  >87 publications with MCM2 and CDC45
 MCM5 antibody  >85 publications with MCM2 and MCM5
 MCM6 antibody  >79 publications with MCM2 and MCM6
 CDC7 antibody  >71 publications with MCM2 and CDC7
 DBF4 antibody  >43 publications with MCM2 and DBF4

Pathways associated with anti-MCM2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram

Organs/Tissues associated with anti-MCM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with MCM2 and Brain
 Blood Antibodies  >24 publications with MCM2 and Blood
 Lung Antibodies  >23 publications with MCM2 and Lung
 Lymph Node Antibodies  >22 publications with MCM2 and Lymph Node
 Lymph Antibodies  >22 publications with MCM2 and Lymph
 Liver Antibodies  >17 publications with MCM2 and Liver
 Bone Antibodies  >16 publications with MCM2 and Bone
 Cervix Antibodies  >15 publications with MCM2 and Cervix
 Mouth Antibodies  >11 publications with MCM2 and Mouth
 Intestine Antibodies  >11 publications with MCM2 and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000