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NDRG1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752980

Description: Rabbit IgG polyclonal antibody for NDRG1 detection. Tested with WB, FCM, Direct ELISA in Human.Background: Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. It is a member of the N-myc downregulated gene family which belong… More details

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Product Overview

Online Datasheet in PDF
Product Name
NDRG1, Polyclonal Antibody
Full Product Name
Anti-NDRG1 Antibody
Product Gene Name
anti-NDRG1 antibody
Product Synonym Names
Protein NDRG1; Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42; NDRG1; CAP43, DRG1, RTP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
601455
3D Structure
ModBase 3D Structure for Q92597
Immunogen
E Coli-derived human NDRG1 recombinant protein (Position: S2-N220).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-NDRG1 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-NDRG1 antibody
WB: 0.25-0.5ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Flow Cytometry (FC/FACS) of anti-NDRG1 antibody

Rabbit Anti-NDRG1 Polyclonal Antibody – Cat# MBS1752980

Western Blot (WB) of anti-NDRG1 antibody

Figure 1. Western blot analysis of NDRG1 using anti-NDRG1 antibody.
Rabbit Anti-NDRG1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1752980

Product References and Citations for anti-NDRG1 antibody

1. Hunter, M., Bernard, R., Freitas, E., Boyer, A., Morar, B., Martins, I. J., Tournev, I., Jordanova, A., Guergelcheva, V., Ishpekova, B., Kremensky, I., Nicholson, G., Schlotter, B., Lochmuller, H., Voit, T., Colomer, J., Thomas, P. K., Levy, N., Kalaydjieva, L. Mutation screening of the N-myc downstream-regulated gene 1 (NDRG1) in patients with Charcot-Marie-Tooth disease. Hum. Mutat. 22: 129-135, 2003.
2. Okamoto, Y., Goksungur, M. T., Pehlivan, D., Beck, C. R., Gonzaga-Jauregui, C., Muzny, D. M., Atik, M. M., Carvalho, C. M. B., Matur, Z., Bayraktar, S., Boone, P. M., Akyuz, K., Gibbs, R. A., Battaloglu, E., Parman, Y., Lupski, J. R. Exonic duplication CNV of NDRG1 associated with autosomal-recessive HMSN-Lom/CMT4D. Genet. Med. 16: 386-394, 2014. Note: Erratum: Genet. Med. 16: 203 only, 2014.
3. Okuda, T., Higashi, Y., Kokame, K., Tanaka, C., Kondoh, H., Miyata, T. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Molec. Cell. Biol. 24: 3949-3956, 2004.

Other Notes

Small volumes of anti-NDRG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDRG1 purchase

MBS1752980 is an antibody targeting NDRG1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NDRG1. It may not necessarily be applicable to this product.

NCBI GI #
207028748
NCBI GeneID
10397
NCBI Accession #
NP_001128714.1
UniProt Primary Accession #
Q92597
UniProt Related Accession #
Q92597
GenBank Nucleotide #
NP_001128714.1
NCBI Official Full Name
protein NDRG1 isoform 1
NCBI Official Synonym Full Names
N-myc downstream regulated 1
NCBI Official Symbol
NDRG1
NCBI Official Synonym Symbols
GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1
UniProt Protein Name
Protein NDRG1
UniProt Synonym Protein Names
Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
Protein Family
Protein
UniProt Gene Name
NDRG1
UniProt Synonym Gene Names
CAP43; DRG1; RTP; DRG-1; RTP
UniProt Entry Name
NDRG1_HUMAN
NCBI Protein Information
protein NDRG1

NCBI Summary for NDRG1

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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Research Articles on NDRG1

1. CCAT2 acts as an oncogene by up-regulating NDRG1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NDRG1 antibody

 Reference Product  PubMed Publications
 MYC antibody  >184 publications with NDRG1 and MYC
 SGK1 antibody  >17 publications with NDRG1 and SGK1
 HIF1A antibody  >15 publications with NDRG1 and HIF1A
 PTEN antibody  >8 publications with NDRG1 and PTEN
 ATF3 antibody  >3 publications with NDRG1 and ATF3
 TP53 antibody  >3 publications with NDRG1 and TP53
 EGR1 antibody  >2 publications with NDRG1 and EGR1
 ARNT antibody  >1 publications with NDRG1 and ARNT

Pathways associated with anti-NDRG1 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram

Diseases associated with anti-NDRG1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >121 publications with NDRG1 and Neoplasms
 Nervous System Diseases Antibodies  >31 publications with NDRG1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >31 publications with NDRG1 and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >22 publications with NDRG1 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >22 publications with NDRG1 and Breast Neoplasms
 Liver Diseases Antibodies  >11 publications with NDRG1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >10 publications with NDRG1 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >9 publications with NDRG1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with NDRG1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >9 publications with NDRG1 and Liver Neoplasms

Organs/Tissues associated with anti-NDRG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >31 publications with NDRG1 and Prostate
 Blood Antibodies  >26 publications with NDRG1 and Blood
 Liver Antibodies  >20 publications with NDRG1 and Liver
 Brain Antibodies  >19 publications with NDRG1 and Brain
 Lung Antibodies  >18 publications with NDRG1 and Lung
 Muscle Antibodies  >16 publications with NDRG1 and Muscle
 Vascular Antibodies  >14 publications with NDRG1 and Vascular
 Lymph Node Antibodies  >13 publications with NDRG1 and Lymph Node
 Bone Antibodies  >11 publications with NDRG1 and Bone
 Heart Antibodies  >10 publications with NDRG1 and Heart
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