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CCR8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9128248
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This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCR8, Polyclonal Antibody
Full Product Name
CCR8 Polyclonal Antibody
Product Gene Name
anti-CCR8 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
41kDa
OMIM
601834
3D Structure
ModBase 3D Structure for P51685
Immunogen
Recombinant protein of human CCR8
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CCR8 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CCR8 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200

Western Blot (WB) of anti-CCR8 antibody

Western blot analysis of extracts of various cell lines, using CCR8 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-CCR8 Polyclonal Antibody – Cat# MBS9128248

Other Notes

Small volumes of anti-CCR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCR8 purchase

MBS9128248 is an antibody targeting CCR8. Also known as CCR8 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR8. It may not necessarily be applicable to this product.

NCBI GI #
4885121
NCBI GeneID
1237
NCBI Accession #
NP_005192.1
UniProt Primary Accession #
P51685
UniProt Secondary Accession #
Q3KNQ8; Q3KNR3; Q9BYX5; B2RC64
UniProt Related Accession #
P51685
GenBank Nucleotide #
NM_005201.3
NCBI Official Full Name
C-C chemokine receptor type 8
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 8
NCBI Official Symbol
CCR8
NCBI Official Synonym Symbols
CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
UniProt Protein Name
C-C chemokine receptor type 8
UniProt Synonym Protein Names
CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CD_antigen: CDw198
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR8
UniProt Synonym Gene Names
CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6
UniProt Entry Name
CCR8_HUMAN
NCBI Protein Information
C-C chemokine receptor type 8

UniProt Comments for CCR8

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; cell adhesion; chemotaxis
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Research Articles on CCR8

1. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR8 antibody

 Reference Product  PubMed Publications
 CCL1 antibody  >102 publications with CCR8 and CCL1
 CCL17 antibody  >34 publications with CCR8 and CCL17
 CCL5 antibody  >26 publications with CCR8 and CCL5
 CCL4 antibody  >24 publications with CCR8 and CCL4
 CXCL10 antibody  >15 publications with CCR8 and CXCL10
 CXCL12 antibody  >12 publications with CCR8 and CXCL12
 CXCL9 antibody  >8 publications with CCR8 and CXCL9
 CCL16 antibody  >8 publications with CCR8 and CCL16
 CCL20 antibody  >7 publications with CCR8 and CCL20
 CCL21 antibody  >1 publications with CCR8 and CCL21

Pathways associated with anti-CCR8 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR8 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >111 publications with CCR8 and Immune System Diseases
 Inflammation Antibodies  >77 publications with CCR8 and Inflammation
 Hypersensitivity Antibodies  >52 publications with CCR8 and Hypersensitivity
 Respiratory Tract Diseases Antibodies  >38 publications with CCR8 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >36 publications with CCR8 and Lung Diseases
 Disease Models, Animal Antibodies  >27 publications with CCR8 and Disease Models, Animal
 Autoimmune Diseases Antibodies  >22 publications with CCR8 and Autoimmune Diseases
 Necrosis Antibodies  >17 publications with CCR8 and Necrosis
 Pneumonia Antibodies  >5 publications with CCR8 and Pneumonia
 Fibrosis Antibodies  >4 publications with CCR8 and Fibrosis

Organs/Tissues associated with anti-CCR8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >190 publications with CCR8 and Blood
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