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PAF1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752996

Description: Rabbit IgG polyclonal antibody for PAF1/PD2 detection. Tested with WB, ICC/IF, Direct ELISA in Human; Mouse; Rat.Background: PAF1 encodes a subunit of the polymerase associated factor (PAF1) complex. It is mapped to 19q13.2. The PAF1 complex… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PAF1/PD2, Polyclonal Antibody
Full Product Name
Anti-PAF1/PD2 Antibody
Product Gene Name
anti-PAF1 antibody
Product Synonym Names
RNA polymerase II-associated factor 1 homolog; hPAF1; Pancreatic differentiation protein 2; PAF1; PD2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
610506
3D Structure
ModBase 3D Structure for Q8N7H5
Immunogen
E Coli-derived human PAF1/PD2 recombinant protein (Position: N18-D355).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PAF1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Direct ELISA (EIA)
Application Notes for anti-PAF1 antibody
WB: 0.1-0.25ug/ml (Human, Mouse, Rat)
ICC: 2ug/ml (Human)
IF: 2ug/ml (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Immunofluorescence (IF) of anti-PAF1 antibody

Rabbit Anti-PAF1 Polyclonal Antibody – Cat# MBS1752996

Western Blot (WB) of anti-PAF1 antibody

Figure 1. Western blot analysis of PAF1 using anti-PAF1 antibody.
Rabbit Anti-PAF1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1752996

Product References and Citations for anti-PAF1 antibody

1. Chen, F. X., Xie, P., Collings, C. K., Cao, K., Aoi, Y., Marshall, S. A., Rendleman, E. J., Ugarenko, M., Ozark, P. A., Zhang, A., Shiekhattar, R., Smith, E. R., Zhang, M. Q., Shilatifard, A. PAF1 regulation of promoter-proximal pause release via enhancer activation. Science 357: 1294-1298, 2017.
2. Marazzi, I., Ho, J. S. Y., Kim, J., Manicassamy, B., Dewell, S., Albrecht, R. A., Seibert, C. W., Schaefer, U., Jeffrey, K. L., Prinjha, R. K., Lee, K., Garcia-Sastre, A., Roeder, R. G., Tarakhovsky, A. Suppression of the antiviral response by an influenza histone mimic. Nature 483: 428-433, 2012.
3. Moniaux, N., Nemos, C., Schmied, B. M., Chauhan, S. C., Deb, S., Morikane, K., Choudhury, A., VanLith, M., Sutherlin, M., Sikela, J. M., Hollingsworth, M. A., Batra, S. K. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Oncogene 25: 3247-3257, 2006.

Other Notes

Small volumes of anti-PAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAF1 purchase

MBS1752996 is an antibody targeting PAF1. Also known as Anti-PAF1/PD2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAF1. It may not necessarily be applicable to this product.

NCBI GI #
378744165
NCBI GeneID
54623
NCBI Accession #
NP_001243755
UniProt Primary Accession #
Q8N7H5
UniProt Related Accession #
Q8N7H5
GenBank Nucleotide #
NP_001243755.1
NCBI Official Full Name
RNA polymerase II-associated factor 1 homolog isoform 2
NCBI Official Synonym Full Names
PAF1 homolog, Paf1/RNA polymerase II complex component
NCBI Official Symbol
PAF1
NCBI Official Synonym Symbols
PD2; F23149_1
UniProt Protein Name
RNA polymerase II-associated factor 1 homolog
UniProt Synonym Protein Names
Pancreatic differentiation protein 2
Protein Family
Proteasome
UniProt Gene Name
PAF1
UniProt Synonym Gene Names
PD2; hPAF1
UniProt Entry Name
PAF1_HUMAN
NCBI Protein Information
RNA polymerase II-associated factor 1 homolog

NCBI Summary for PAF1

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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Research Articles on PAF1

1. These data highlight that human PAF1C is an important transcriptional regulator of expanded G4C2 within C9orf72

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAF1 antibody

 Reference Product  PubMed Publications
 CDC73 antibody  >46 publications with PAF1 and CDC73
 RTF1 antibody  >45 publications with PAF1 and RTF1
 CTR9 antibody  >31 publications with PAF1 and CTR9
 LEO1 antibody  >26 publications with PAF1 and LEO1
 SUPT5H antibody  >3 publications with PAF1 and SUPT5H
 ELP3 antibody  >1 publications with PAF1 and ELP3

Diseases associated with anti-PAF1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with PAF1 and Inflammation
 Liver Diseases Antibodies  >1 publications with PAF1 and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with PAF1 and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with PAF1 and Congenital Abnormalities
 Cognition Disorders Antibodies  >1 publications with PAF1 and Cognition Disorders

Organs/Tissues associated with anti-PAF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >11 publications with PAF1 and Parathyroid
 Kidney Antibodies  >5 publications with PAF1 and Kidney
 Blood Antibodies  >5 publications with PAF1 and Blood
 Heart Antibodies  >4 publications with PAF1 and Heart
 Embryonic Tissue Antibodies  >3 publications with PAF1 and Embryonic Tissue
 Bone Antibodies  >2 publications with PAF1 and Bone
 Muscle Antibodies  >2 publications with PAF1 and Muscle
 Intestine Antibodies  >1 publications with PAF1 and Intestine
 Skin Antibodies  >1 publications with PAF1 and Skin
 Spleen Antibodies  >1 publications with PAF1 and Spleen
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